Activating Compound | Comment | Organism | Structure |
---|---|---|---|
MKK3 | activation of p38alpha occurs through bisphosphorylation by the dual-specificity Ser/Thr MAP kinases MKK3 and MKK6 on the Thr180-Gly181-Tyr182 motif located on the activation loop | Homo sapiens | |
MKK6 | activation of p38alpha occurs through bisphosphorylation by the dual-specificity Ser/Thr MAP kinases MKK3 and MKK6 on the Thr180-Gly181-Tyr182 motif located on the activation loop | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3-amino-1-oxido-2-phenylpyridin-4-yl)(phenyl)methanone | - |
Homo sapiens | |
4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-3-methyl-N-(2-morpholin-4-ylethyl)benzamide | - |
Homo sapiens | |
4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-3-methylbenzoic acid | - |
Homo sapiens | |
4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-N-(2-methoxyethyl)-3-methylbenzamide | - |
Homo sapiens | |
[3-amino-2-(1,3-benzodioxol-4-yl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,3-dimethoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,4-difluorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,6-dichlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,6-difluoro-4-methoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,6-difluorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,6-dimethoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2,6-dimethylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-chlorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-methoxyphenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-trifluoromethylphenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](phenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-isopropylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-methoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](phenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(3-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(4-chloro-2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(4-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(4-chlorophenyl)-1-oxidopyridin-4-yl](phenyl)methanone | - |
Homo sapiens | |
[3-amino-2-(4-hydroxy-2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-[2-methyl-4-(2-morpholin-4-ylethoxy)phenyl]-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens | |
[3-amino-2-[4-(2-methoxyethoxy)-2-methylphenyl]-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16539 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | whole blood assay | Homo sapiens | - |
THP-1 cell | THP-1 assay | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + ATF2 | substrate in assay, biotinylated ATF2 | Homo sapiens | ADP + a phosphorylated ATF2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p38 mitogen activated protein kinase | - |
Homo sapiens |
p38alpha MAP kinase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
kinase inhibition assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
- |
Homo sapiens | [3-amino-2-(2,6-difluoro-4-methoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000008 | - |
- |
Homo sapiens | [3-amino-2-(4-hydroxy-2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000009 | - |
- |
Homo sapiens | [3-amino-2-(2,6-dichlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000014 | - |
- |
Homo sapiens | [3-amino-2-[2-methyl-4-(2-morpholin-4-ylethoxy)phenyl]-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000015 | - |
- |
Homo sapiens | [3-amino-2-(2,6-dimethoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000017 | - |
- |
Homo sapiens | [3-amino-2-(2,6-difluorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000017 | - |
- |
Homo sapiens | [3-amino-2-(2,6-dimethylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.00002 | - |
- |
Homo sapiens | [3-amino-2-[4-(2-methoxyethoxy)-2-methylphenyl]-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000021 | - |
- |
Homo sapiens | [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000023 | - |
- |
Homo sapiens | [3-amino-2-(2-methoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000024 | - |
- |
Homo sapiens | [3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-chlorophenyl)methanone | |
0.000024 | - |
- |
Homo sapiens | [3-amino-2-(1,3-benzodioxol-4-yl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000037 | - |
- |
Homo sapiens | [3-amino-2-(2,3-dimethoxyphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000038 | - |
- |
Homo sapiens | [3-amino-2-(4-chloro-2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000039 | - |
- |
Homo sapiens | [3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000042 | - |
- |
Homo sapiens | 4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-3-methyl-N-(2-morpholin-4-ylethyl)benzamide | |
0.00007 | - |
- |
Homo sapiens | 4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-N-(2-methoxyethyl)-3-methylbenzamide | |
0.000126 | - |
- |
Homo sapiens | [3-amino-2-(2,4-difluorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000149 | - |
- |
Homo sapiens | [3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-methoxyphenyl)methanone | |
0.000174 | - |
- |
Homo sapiens | [3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](phenyl)methanone | |
0.000208 | - |
- |
Homo sapiens | [3-amino-2-(2-isopropylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000228 | - |
- |
Homo sapiens | [3-amino-2-(3-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000411 | - |
- |
Homo sapiens | [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](phenyl)methanone | |
0.000491 | - |
- |
Homo sapiens | 4-[3-amino-4-(2,4-difluorobenzoyl)-1-oxidopyridin-2-yl]-3-methylbenzoic acid | |
0.000802 | - |
- |
Homo sapiens | [3-amino-2-(4-chlorophenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | |
0.000967 | - |
- |
Homo sapiens | (3-amino-1-oxido-2-phenylpyridin-4-yl)(phenyl)methanone | |
0.001655 | - |
- |
Homo sapiens | [3-amino-2-(2-chlorophenyl)-1-oxidopyridin-4-yl](2-trifluoromethylphenyl)methanone | |
0.00253 | - |
- |
Homo sapiens | [3-amino-2-(4-chlorophenyl)-1-oxidopyridin-4-yl](phenyl)methanone |