Cloned (Comment) | Organism |
---|---|
a pDEST_JNK3_39-402 construct is used for the expression of the protein in Escherichia coli BL21DE3 cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
the structure of SR3737 and SR3451-soaked JNK3 crystals are solved at 2.20 and 2.29 A, respectively | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SR3451 | - |
Homo sapiens | |
SR3451 | - |
Mammalia | |
SR3576 | - |
Homo sapiens | |
SR3576 | - |
Mammalia | |
SR3582 | - |
Homo sapiens | |
SR3582 | - |
Mammalia | |
SR3583 | - |
Homo sapiens | |
SR4018 | - |
Homo sapiens | |
SR4018 | - |
Mammalia | |
SR4276 | - |
Homo sapiens | |
SR4276 | - |
Mammalia | |
SR4326 | - |
Homo sapiens | |
SR4326 | - |
Mammalia | |
SR4642 | - |
Homo sapiens | |
SR4642 | - |
Mammalia | |
SR4643 | - |
Homo sapiens | |
SR4643 | - |
Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Mammalia | - |
ADP + a phosphoprotein | - |
? | |
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Purification (Comment) | Organism |
---|---|
a SP Fastflow column, a Mono S column, and a Sephacryl S200 column are used | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Mammalia | ADP + a phosphoprotein | - |
? | |
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + ATF-2 | - |
Homo sapiens | ADP + phosphorylated ATF-2 | - |
? | |
ATP + c-Jun | - |
Homo sapiens | ADP + phosphorylated c-Jun | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-jun N-terminal kinase 1 | - |
Mammalia |
c-Jun N-terminal kinase 3 | - |
Homo sapiens |
JNK1 | - |
Mammalia |
JNK3 | - |
Homo sapiens |
p38 mitogen-activated protein kinase | - |
Mammalia |
p38MAPK | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia | |
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000007 | - |
- |
Homo sapiens | SR3576 | |
0.000023 | - |
- |
Homo sapiens | SR3582 | |
0.000025 | - |
- |
Homo sapiens | SR3451 | |
0.000055 | - |
- |
Homo sapiens | SR4326 | |
0.00017 | - |
- |
Mammalia | SR3576 | |
0.00035 | - |
- |
Homo sapiens | SR4276 | |
0.0004 | - |
- |
Mammalia | SR3451 | |
0.00048 | - |
- |
Homo sapiens | SR3583 | |
0.00056 | - |
- |
Mammalia | SR3582 | |
0.0014 | - |
- |
Mammalia | SR4326 | |
0.0015 | - |
- |
Homo sapiens | SR4643 | |
0.0021 | - |
- |
Homo sapiens | SR4018 | |
0.0022 | - |
- |
Homo sapiens | SR4642 | |
0.0037 | - |
- |
Mammalia | SR3451 | |
0.02 | - |
larger than 0.020 | Mammalia | SR3582 | |
0.02 | - |
larger than 0.020 | Mammalia | SR3576 | |
0.02 | - |
larger than 0.020 | Mammalia | SR4326 | |
0.02 | - |
larger than 0.020 | Mammalia | SR4642 | |
0.02 | - |
larger than 0.020 | Mammalia | SR4643 | |
0.02 | - |
larger than 0.020 | Mammalia | SR4018 | |
0.02 | - |
larger than 0.020 | Mammalia | SR4276 |