Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activated by a range of stress stimuli | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | JNK inhibitors are expected to be effective therapeutic agents against a variety of diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3,4-thiadiazol-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol | - |
Homo sapiens | |
5-(5-nitrothiazol-2-ylthio)-N-((tetrahydrofuran-2-yl)methyl)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
5-(5-nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
N-(2-methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
N-(3,4-dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
N-(4-methoxybenzyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
N-ethyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens | |
N-sec-butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
JNK1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + ATF2 | substrate in in vitro kinase assay, LanthaScreen | Homo sapiens | ADP + phosphorylated ATF2 | - |
? | |
ATP + c-Jun transcription factor | JNK phosphorylates the N-terminal transactivation domain of c-Jun transcription factor | Homo sapiens | ADP + phosphorylated c-Jun transcription factor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase | - |
Homo sapiens |
JNK | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
in vitro kinase assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
in vitro kinase assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | N-(4-methoxybenzyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.0001 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | N-(3,4-dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.0001 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | N-ethyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.00014 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | N-sec-butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.00016 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | N-(2-methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.00028 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3,4-thiadiazol-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol | |
0.00029 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | 5-(5-nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine | |
0.00047 | - |
pepJIP1 displacement assay DELFIA, GST-JNK2 is applied | Homo sapiens | 5-(5-nitrothiazol-2-ylthio)-N-((tetrahydrofuran-2-yl)methyl)-1,3,4-thiadiazol-2-amine | |
0.0005 | - |
- |
Homo sapiens | 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[(5-nitro-1,3,4-thiadiazol-2-yl)sulfanyl]-4H-1,2,4-triazol-3-ol | |
0.003 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | N-sec-butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.0048 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | N-(2-methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.0057 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | N-(3,4-dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.0067 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | 5-(5-nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine | |
0.0091 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | N-(4-methoxybenzyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine | |
0.01 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | 5-(5-nitrothiazol-2-ylthio)-N-((tetrahydrofuran-2-yl)methyl)-1,3,4-thiadiazol-2-amine | |
0.1 | - |
JNK1 kinase inhibition assay LANTHA | Homo sapiens | N-ethyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | up-regulation of JNK activity is associated with a number of disease states such as type-2 diabetes, obesity, cancer, inflammation, and stroke | up |