Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activated by a range of stress stimuli, such as heat shock, irradiation, hypoxia, chemotoxins, and peroxides, also activated in response to various cytokines | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
2,2'-disulfanediylbis(1,3-benzothiazole) | - |
Homo sapiens | |
2-[(2,4-dinitrophenyl)sulfanyl]-1,3-benzoxazole | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole-5-sulfonic acid | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-5-(trifluoromethyl)-1H-benzimidazole | - |
Homo sapiens | |
2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl][1,3]thiazolo[4,5-b]pyridine | - |
Homo sapiens | |
4-[(1H-benzimidazol-2-ylsulfanyl)methyl]benzoic acid | - |
Homo sapiens | |
4-[[(6-amino-9H-purin-8-yl)sulfanyl]methyl]benzoic acid | - |
Homo sapiens | |
5,6-dichloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
5-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
5-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | - |
Homo sapiens | |
5-methoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
5-methoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
5-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
5-nitro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | - |
Homo sapiens | |
6-chloro-2-[(4-methyl-5-thiophen-2-yl-4H-1,2,4-triazol-3-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-chloro-2-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-chloro-2-[[5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-chloro-2-[[5-(2-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-ethoxy-1,3-benzothiazole-2-sulfonamide | - |
Homo sapiens | |
6-ethoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | - |
Homo sapiens | |
6-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | - |
Homo sapiens | |
6-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-9H-purin-2-amine | - |
Homo sapiens | |
6-[5-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl]quinoline | - |
Homo sapiens | |
8-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-9H-purin-6-amine | - |
Homo sapiens | |
pep-JIP1 | peptide corresponding to the D-domain of JIP-1, final sequence of the most extensively used peptide is GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT | Homo sapiens | |
S-1,3-benzothiazol-2-yl (2Z)-(2-amino-1,3-thiazol-4-yl)(methoxyimino)ethanethioate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
ATP + ATF2 | substrate in in vitro kinase assay, LanthaScreen | Homo sapiens | ADP + phosphorylated ATF2 | - |
? | |
ATP + c-Jun transcription factor | JNK phosphorylates the N-terminal transactivation domain of c-Jun transcription factor | Homo sapiens | ADP + phosphorylated c-Jun transcription factor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-Jun N-terminal kinase | - |
Homo sapiens |
JNK | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0018 | - |
- |
Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | |
0.0018 | - |
- |
Homo sapiens | 5-methoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | |
0.0027 | - |
- |
Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | |
0.0038 | - |
- |
Homo sapiens | 5-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.0042 | - |
- |
Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl][1,3]thiazolo[4,5-b]pyridine | |
0.0047 | - |
- |
Homo sapiens | 5-methoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.0064 | - |
- |
Homo sapiens | 5-nitro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.0081 | - |
- |
Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.0202 | - |
- |
Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-5-(trifluoromethyl)-1H-benzimidazole | |
0.023 | - |
- |
Homo sapiens | 5,6-dichloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.027 | - |
- |
Homo sapiens | 5-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | |
0.027 | - |
- |
Homo sapiens | 8-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-9H-purin-6-amine | |
0.05 | - |
- |
Homo sapiens | 2,2'-disulfanediylbis(1,3-benzothiazole) | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-ethoxy-1,3-benzothiazole-2-sulfonamide | |
0.05 | - |
larger than 0.050 | Homo sapiens | 1-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-benzimidazole-5-sulfonic acid | |
0.05 | - |
larger than 0.050 | Homo sapiens | 5-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-chloro-2-[(4-methyl-5-thiophen-2-yl-4H-1,2,4-triazol-3-yl)sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-chloro-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-chloro-2-[[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-chloro-2-[[5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-chloro-2-[[5-(2-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-ethoxy-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-methyl-2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzoxazole | |
0.05 | - |
larger than 0.050 | Homo sapiens | 6-[5-[(6-chloro-1,3-benzothiazol-2-yl)sulfanyl]-4-methyl-4H-1,2,4-triazol-3-yl]quinoline | |
0.05 | - |
larger than 0.050 | Homo sapiens | S-1,3-benzothiazol-2-yl (2Z)-(2-amino-1,3-thiazol-4-yl)(methoxyimino)ethanethioate | |
0.055 | - |
- |
Homo sapiens | 6-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-9H-purin-2-amine | |
0.07 | - |
- |
Homo sapiens | 4-[[(6-amino-9H-purin-8-yl)sulfanyl]methyl]benzoic acid | |
0.1 | - |
larger than 0.100 | Homo sapiens | 2-[(2,4-dinitrophenyl)sulfanyl]-1,3-benzoxazole | |
0.1 | - |
larger than 0.100 | Homo sapiens | 4-[(1H-benzimidazol-2-ylsulfanyl)methyl]benzoic acid |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | up-regulation of JNK activity is associated with a number of disease states such as type-2 diabetes, obesity, cancer, inflammation, and stroke | up |