Literature summary for 2.7.11.24 extracted from

Hamel, M.G.; Ajmo, J.M.; Leonardo, C.C.; Zuo, F.; Sandy, J.D.; Gottschall, P.E.
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension (2008), Exp. Neurol., 210, 428-440.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ADAMTS4	EC 3.4.24.82	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
PD98059	inhibition of neurite outgrowth induced by ADAMTS4 treatment	Rattus norvegicus
U0126	inhibition of neurite outgrowth induced by ADAMTS4 treatment	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Rattus norvegicus	-
cerebral cortex	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
ERK 1/2	-	Rattus norvegicus
MAP ERK 1/2 kinase	-	Rattus norvegicus
MAP kinase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
additional information	involvement of the MAP kinase signaling pathway in ADAMTS4-stimulated neurite outgrowth	Rattus norvegicus

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Release 2023.1 (January 2023)