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Literature summary for 2.7.11.24 extracted from

  • Hao, N.; Zeng, Y.; Elston, T.C.; Dohlman, H.G.
    Control of MAP kinase specificity by feedback phosphorylation of a shared adaptor protein Ste50 (2008), J. Biol. Chem., 283, 33798-33802.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information osmotic stress activates Hog1. Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 Saccharomyces cerevisiae
additional information osmotic stress activates Kss1. Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Ste50 Saccharomyces cerevisiae Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview ADP + phosphorylated Ste50
-
 ?
ATP + Ste50 Saccharomyces cerevisiae Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview ADP + phosphorylated Ste50
-
 ?
additional information Saccharomyces cerevisiae the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview ?
-
 ?
additional information Saccharomyces cerevisiae the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P14681 Kss1
-
Saccharomyces cerevisiae P32485 Hog1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 Saccharomyces cerevisiae
phosphoprotein Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Ste50 Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview Saccharomyces cerevisiae ADP + phosphorylated Ste50
-
 ?
ATP + Ste50 Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview Saccharomyces cerevisiae ADP + phosphorylated Ste50
-
 ?
additional information the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview Saccharomyces cerevisiae ?
-
 ?
additional information the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Hog1
-
 Saccharomyces cerevisiae
Kss1
-
 Saccharomyces cerevisiae
MAP kinase
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae