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Literature summary for 2.7.11.24 extracted from

  • Chen, L.; Liu, L.; Huang, S.
    Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5 (2008), Free Radic. Biol. Med., 45, 1035-1044.
    View publication on PubMed

Application

Application Comment Organism
medicine the inhibitors of Erk1 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Rattus norvegicus
medicine the inhibitors of Erk1 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Homo sapiens
medicine the inhibitors of Erk2 or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Homo sapiens
medicine the inhibitors of Erk2, or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Rattus norvegicus
medicine the inhibitors of JNK or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Homo sapiens
medicine the inhibitors of JNK, or antioxidants may be exploited for prevention of cadmium-induced neurodegenerative diseases Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1; overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2; overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK Homo sapiens
additional information overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1; overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2; overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK Rattus norvegicus
SP600125 inhibitor of JNK Homo sapiens
SP600125 inhibitor of JNK Rattus norvegicus
U0126 inhibitor of Erk1; inhibitor of Erk2 Homo sapiens
U0126 inhibitor of Erk1; inhibitor of Erk2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview ?
-
?
additional information Homo sapiens cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview ?
-
?
additional information Homo sapiens cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview ?
-
?
additional information Rattus norvegicus cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview ?
-
?
additional information Homo sapiens cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview ?
-
?
additional information Rattus norvegicus cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P27361 Erk1
-
Homo sapiens P28482 ERK2
-
Rattus norvegicus
-
-
-
Rattus norvegicus P21708 Erk1
-
Rattus norvegicus P63086 ERK2
-

Source Tissue

Source Tissue Comment Organism Textmining
neuroblastoma cell
-
Homo sapiens
-
PC-12 cell
-
Rattus norvegicus
-
SH-SY5Y cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview Rattus norvegicus ?
-
?
additional information cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview Homo sapiens ?
-
?
additional information cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview Homo sapiens ?
-
?
additional information cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview Rattus norvegicus ?
-
?
additional information cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview Homo sapiens ?
-
?
additional information cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
c-Jun N-terminal kinase
-
Homo sapiens
c-Jun N-terminal kinase
-
Rattus norvegicus
ERK1
-
Rattus norvegicus
ERK1
-
Homo sapiens
ERK2
-
Homo sapiens
ERK2
-
Rattus norvegicus
extracellular signal-regulated kinase 1
-
Rattus norvegicus
extracellular signal-regulated kinase 1
-
Homo sapiens
extracellular signal-regulated kinase 2
-
Homo sapiens
extracellular signal-regulated kinase 2
-
Rattus norvegicus
JNK
-
Homo sapiens
JNK
-
Rattus norvegicus
MAPK
-
Homo sapiens
MAPK
-
Rattus norvegicus