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Literature summary for 2.7.11.24 extracted from

  • Heinrichsdorff, J.; Luedde, T.; Perdiguero, E.; Nebreda, A.R.; Pasparakis, M.
    p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure (2008), EMBO Rep., 9, 1048-1054.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information MAPKs are activated by phosphorylation through MAPK kinases, overview. TNF induces p38 MAP kinase, JNK is induced by TNF and lipopolysaccharide Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of mutant knockout p38alphaLPC-KO mice, hepatocyte-specific ablation of p38alpha in mice results in activation of MKK4 and MKK3/6 and excessive activation of JNK in the liver after in vivo challenge with bacterial lipopolysaccharide. Despite increased JNK activity, p38alpha-deficient hepatocytes are not sensitive to LPS/TNF toxicity showing that JNK activation is not sufficient to mediate TNF-induced liver damage. Lipopolysaccharide injection causes liver failure in mice lacking both p38alpha and IkappaB kinase 2 in hepatocytes, when combined with partial nuclear factor-kappaB inhibition, p38alpha deficiency sensitizes the liver to cytokine-induced damage Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview ?
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additional information Mus musculus C57BL/6 activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P47811 C57BL/6 mice
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Mus musculus C57BL/6 P47811 C57BL/6 mice
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein p38alpha MAPK are activated by phosphorylation through MAPK kinases, e.g. MKK3 and MKK6, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
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 Mus musculus
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hepatocyte
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 Mus musculus
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liver
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview Mus musculus ?
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 ?
additional information activation of JNK facilitates tumour necrosis factor-induced cell death. The p38 mitogen-activated protein kinase pathway is induced by TNF-stimulation, but it is not involved in TNF-induced cell death. p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. p38alpha MAPK inhibits MKK4, and MKK3/6, regulation, overview Mus musculus C57BL/6 ?
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 ?

Synonyms

Synonyms Comment Organism
c-Jun amino-terminal kinase
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 Mus musculus
JNK
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 Mus musculus
p38alpha MAPK
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 Mus musculus