Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.24 extracted from

  • Murphy, L.O.; Blenis, J.
    MAPK signal specificity: the right place at the right time (2006), Trends Biochem. Sci., 31, 268-275.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
Epidermal growth factor induces potent transient activation of the ERK pathway Rattus norvegicus
Insulin causes weak activation Rattus norvegicus
additional information cell-surface receptor density, expression of scaffolding proteins, the surrounding extracellular matrix, and the interplay between kinases and phosphatases modulate the strength and duration of ERK signaling, c-Fos transcription factor can function as a sensor for ERK activation dynamics Rattus norvegicus
additional information ERK activation in oocytes can be bistable or irreversible owing to a strong positive feedback loop regulated by the Mos kinase Xenopus sp.
nerve growth factor alters outcome of ERK signaling Rattus norvegicus
Ras essential for ERK activation, the three isoforms N-Ras, K-Ras and H-Ras have an important role in spatial and temporal ERK signaling Rattus norvegicus

Application

Application Comment Organism
medicine ERK signaling is involved in cell cycle progression, cellular transformation and differentation. Spatial distribution and temporal qualities of ERK can markedly alter the qualitative and quantitative features of downstream signaling to immediate early genes and the expression of immediate early genes-encoded protein products. Targeting of ERK/DEF domain signaling axis may be beneficial in many cancers Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
MKP1/2 may dampen ERK activity during the G1/S transition, is involved in reducing strength and duration of ERK signaling Rattus norvegicus
MKP3 selective for ERK1 and 2 Rattus norvegicus
additional information genes encoding Sef prevent dissociation of the MEK-ERK complex, thereby inhibiting translocation of ERK to the nucleus, but ERK can still signal to cytoplasmic targets Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-
nucleus
-
 Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Xenopus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
 Xenopus sp.
-
PC-12 cell activation of ERK signaling precedes differentiation of PC12 pheochromocytoma cells into sympathetic-like neurons Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Elk1
-
 Rattus norvegicus ADP + phosphorylated Elk1
-
 ?
ATP + JunD
-
 Rattus norvegicus ADP + phosphorylated JunD
-
 ?
ATP + MEK
-
 Rattus norvegicus ADP + phosphorylated MEK binding to ERK requires docking domain and the kinase interaction motif ?
ATP + RSK
-
 Rattus norvegicus ADP + phosphorylated RSK binding to ERK requires docking domain ?

Synonyms

Synonyms Comment Organism
ERK
-
 Xenopus sp.
ERK1
-
 Rattus norvegicus
ERK2
-
 Rattus norvegicus
extracellular signal-regulated kinase
-
 Rattus norvegicus
extracellular signal-regulated kinase
-
 Xenopus sp.