Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | MKK6-DD phosphorylates the p38a-MK2 heterodimer | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure of the unphosphorylated p38alpha-MK2, by hanging drop method, full-length p38alpha-MK2 complex to 4 A resolution, belongs to spacegroup P41 with unit cell dimensions of 103.09 A, 103.09 A, 231.42 A, 90.0°, 90.0°, 90.0°, p38alpha-MK2 peptide complex, belongs to spacegroup P31 with unit cell dimensions of 81.55 A, 81.55 A, 121.36 A, 90.0°, 90.0°, 120.0°. C-terminal regulatory domain of MK2 binds in the docking groove of p38alpha, and the ATP-binding sites of both kinases are at the heterodimer interface | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SB203580 | inhibits MK2 phosphorylation | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + MK2 | - |
Homo sapiens | ADP + phosphorylated MK2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P38alpha-MAPKAP kinase 2 | - |
Homo sapiens |