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Literature summary for 2.7.11.24 extracted from

  • Torii, S.; Nakayama, K.; Yamamoto, T.; Nishida, E.
    Regulatory mechanisms and function of ERK MAP kinases (2004), J. Biochem., 136, 557-561.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation activates ERK Danio rerio
additional information the factors Sprouty1 and Sprouty2 are involved in ERK regulation, mechanism, phosphorylation activates ERK vertebrata

Inhibitors

Inhibitors Comment Organism Structure
additional information molecular mechanism of negative regulation of Ras/ERK signaling, Sef negatively regulates ERK phosphorylation by blocking dissocation of MEK and ERK Danio rerio
additional information molecular mechanism of negative regulation of Ras/ERK signaling, Sef negatively regulates ERK phosphorylation by blocking dissocation of MEK and ERK vertebrata

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus vertebrata 5737
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cytoplasm ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus Danio rerio 5737
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Golgi apparatus ERK colocalizes with MEK and Sef vertebrata 5794
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Golgi apparatus ERK colocalizes with MEK and Sef Danio rerio 5794
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nucleus ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus, mechanism vertebrata 5634
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nucleus ERK localization is controlled by the cytoplasmic ERK anchoring proteins that have a nuclear export signal, ERK forms complexes with MEK, EC 2.7.11.25, in the cytoplasm, in response to activation ERK dissociates from MEK and is translocated to the nucleus, mechanism Danio rerio 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information vertebrata spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling ?
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 ?
additional information Danio rerio spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling ?
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 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
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vertebrata
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation activates ERK Danio rerio
phosphoprotein the MAPK is phosphorylated and activated in the MAPK signaling cascade by 2 mechanisms: 1. by MEKs, EC 2.7.11.25, docking at the ED domain or the CD domain of MAPKs, or 2. by MKK7, MLK, JNK or MKP-7 docking at the scaffolding protein JIP in the JNK signaling pathway vertebrata

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling vertebrata ?
-
 ?
additional information spatiotemporal control of the Ras/ERK MAP kinase signaling pathway, involving multiple factors, is a key factor for determining the specificity of cellular responses including cell proliferation, cell differentiation, and cell survival, the fidelity of the signaling is regulated by docking interactions and by scaffolding, molecular mechanism of negative regulation of Ras/ERK signaling Danio rerio ?
-
 ?
phosphoprotein the MAPK is regulated in the MAPK signaling cascade by 2 mechanisms: 1. by MEK, EC 2.7.11.25, docking at the allosteric ED domain or the CD domain of MAPKs, or 2. by MKK7, MLK, JNK or MKP-7 docking at the scaffolding protein JIP in the JNK signaling pathway vertebrata ?
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 ?

Synonyms

Synonyms Comment Organism
ERK
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 vertebrata
ERK
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 Danio rerio
MAP kinase
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 vertebrata
MAPK
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 vertebrata