Literature summary for 2.7.11.24 extracted from

Lee, J.Y.; Yu, B.P.; Chung, H.Y.
Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide (2005), Free Radic. Res., 39, 399-409.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	tert-butyl hydroperoxide, causing oxidative stress incells, induces activation of ERK and p38 MAP kinase by increased phosphorylation, MAPKs are activated in response to intracellular reactive species, MAPK signaling cascade activation mechanism, overview	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
PD98059	inhibits ERK1 and ERK2	Rattus norvegicus
SB203580	inhibits p38 MAP kinase	Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
42000	-	x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE	Rattus norvegicus
44000	-	x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	ERK1 and ERK2 are activated by phosphorylation at Thr and Tyr residues, p38 MAPK is activated by phosphorylation at Thr180 and Tyr182	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelium	prostate endothelial cells	Rattus norvegicus	-
prostate gland	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process	Rattus norvegicus	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 44000, ERK1, SDS-PAGE, x * 42000, ERK2, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
ERK1	-	Rattus norvegicus
ERK2	-	Rattus norvegicus
extracellular-regulated kinase	-	Rattus norvegicus
JNK	-	Rattus norvegicus
MAP kinase	-	Rattus norvegicus
p38 MAP kinase	-	Rattus norvegicus
SAPK	-	Rattus norvegicus
stress-activated protein kinase	-	Rattus norvegicus

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Release 2023.1 (January 2023)