Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EGF | induces phosphorylation of Smad3 | Mus musculus | |
additional information | ERK2 is activated by phosphorylation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PD98059 and U0126 inhibit EGF-induced phosphorylation of Smad3 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Smad3 | Mus musculus | substrate of MAPKs, e.g. ERK2 | ADP + phosphorylated Smad3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | ERK2 is activated by phosphorylation | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
myoblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Elk1 | recombinant GST-tagged Elk1, substrate of ERK2 | Mus musculus | ADP + phosphorylated Elk1 | - |
? | |
ATP + myelin basic protein | substrate of ERK2 | Mus musculus | ADP + phosphorylated myelin basic protein | - |
? | |
ATP + Smad3 | substrate of MAPKs, e.g. ERK2 | Mus musculus | ADP + phosphorylated Smad3 | - |
? | |
ATP + Smad3 | substrate of MAPKs, e.g. ERK2, identification of phosphorylation sites Ser203, Ser207, and Thr187, Ser207 is the best phosphorylation site for ERK2, other MAPKs than ERK2 also phosphorylate Ser212 | Mus musculus | ADP + phosphorylated Smad3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ERK | - |
Mus musculus |
ERK2 | - |
Mus musculus |
MAP kinase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |