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Literature summary for 2.7.11.24 extracted from
- Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions (2003), Biochem. J., 372, 1-13.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | interaction motifs, i.e. docking sites or recognition sequences, of substrates are crucial for MAPK activity, i.e. motif Leu-Xaa-Leu preceded by 3-5 basic residues, overview | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure of p38alpha, show docking grooves for binding of substrate D-domains, i.e. of MEF2A, and of activating kinases, e.g. of MKK3b, Ile116 and Gln120 play important roles | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | MAPK activate mitogen-activated proteins in several signal transduction pathways, overview | ADP + a phosphoprotein | - |
? |  |
| ATP + c-Jun | Homo sapiens | substrate of JNK | ADP + phosphorylated c-Jun | - |
? | |
| ATP + Lin-1 | Homo sapiens | substrate of ERK2, negative regulation of Lin-1 | ADP + phosphorylated Lin-1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P53778 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + a protein | MAPK activate mitogen-activated proteins in several signal transduction pathways, overview | Homo sapiens | ADP + a phosphoprotein | - |
? | |
| ATP + c-Jun | substrate of JNK | Homo sapiens | ADP + phosphorylated c-Jun | - |
? | |
| ATP + c-Jun | substrate of JNK, binding via delta domain of c-Jun substrate | Homo sapiens | ADP + phosphorylated c-Jun | - |
? | |
| ATP + Lin-1 | substrate of ERK2, negative regulation of Lin-1 | Homo sapiens | ADP + phosphorylated Lin-1 | - |
? | |
| ATP + Lin-1 | Lin-1 is an ETS transcription factor, substrate of ERK2, binding via the docking sequence of the substrate | Homo sapiens | ADP + phosphorylated Lin-1 | - |
? | |
| additional information | interaction motifs of substrates are crucial for MAPK activity, motif Leu-Xaa-Leu preceded by 3-5 basic residues is abundant, docking mechanism in MAPK signalling, the recognition modules can function synergistically or competitively, MAPK determinants recognizing docking motifs, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ERK | - |
Homo sapiens |
| JNK | - |
Homo sapiens |
| MAPK | - |
Homo sapiens |
| p38 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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