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Literature summary for 2.7.11.24 extracted from

  • Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
    The specificities of protein kinase inhibitors: an update (2003), Biochem. J., 371, 199-204.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
purvalanol 17% activation of SAPK2b/p38beta Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alsterpaullone inhibition of JNK/SAPK1c, SAPK2a/p38, SAPK2b/p38beta, SAPK3/p38gamma, and SAPK4/p38delta Homo sapiens
alsterpaullone 36% inhibition of MAPK2/ERK2 at 0.01 mM Mus musculus
indirubin-3'-monoxime 79% inhibition at 0.01 mM of JNK/SAPK1c, 17% inhibition at 0.01 mM of SAPK2a/p38, 55% inhibition at 0.01 mM of SAPK2b/p38beta, 26% inhibition at 0.01 mM of SAPK3/p38gamma, and 35% inhibition at 0.01 mM of SAPK4/p38delta Homo sapiens
kenpaullone slight inhibition of SAPK2a/p38 and SAPK3/p38gamma, no inhibition of SAPK4/p38delta, JNK/SAPK1c, SAPK2b/p38beta, and SAPK4/p38delta Homo sapiens
kenpaullone 30% inhibition of MAPK2/ERK2 at 0.01 mM Mus musculus
additional information roscovitine is a poor inhibitor of MAPKs Homo sapiens
additional information indirubin-3'-monoxime is no inhibitor of MAPK2/ERK2 Mus musculus
purvalanol 16% inhibition at 0.01 mM of JNK/SAPK1c, no inhibition of SAPK2a/p38, SAPK3/p38gamma, and SAPK4/p38delta Homo sapiens
purvalanol 74% inhibition of MAPK2/ERK2 at 0.01 mM Mus musculus
roscovitine 19% inhibition of MAPK2/ERK2 at 0.01 mM Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Synonyms

Synonyms Comment Organism
ERK2
-
Mus musculus
JNK/SAPK1c
-
Homo sapiens
MAPK2
-
Mus musculus
SAPK2a/p38
-
Homo sapiens
SAPK2b/p38beta
-
Homo sapiens
SAPK3/p38gamma
-
Homo sapiens
SAPK4/p38delta
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
21
-
assay at room temperature Mus musculus
21
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Mus musculus
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens