Activating Compound | Comment | Organism | Structure |
---|---|---|---|
purvalanol | 17% activation of SAPK2b/p38beta | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alsterpaullone | inhibition of JNK/SAPK1c, SAPK2a/p38, SAPK2b/p38beta, SAPK3/p38gamma, and SAPK4/p38delta | Homo sapiens | |
alsterpaullone | 36% inhibition of MAPK2/ERK2 at 0.01 mM | Mus musculus | |
indirubin-3'-monoxime | 79% inhibition at 0.01 mM of JNK/SAPK1c, 17% inhibition at 0.01 mM of SAPK2a/p38, 55% inhibition at 0.01 mM of SAPK2b/p38beta, 26% inhibition at 0.01 mM of SAPK3/p38gamma, and 35% inhibition at 0.01 mM of SAPK4/p38delta | Homo sapiens | |
kenpaullone | slight inhibition of SAPK2a/p38 and SAPK3/p38gamma, no inhibition of SAPK4/p38delta, JNK/SAPK1c, SAPK2b/p38beta, and SAPK4/p38delta | Homo sapiens | |
kenpaullone | 30% inhibition of MAPK2/ERK2 at 0.01 mM | Mus musculus | |
additional information | roscovitine is a poor inhibitor of MAPKs | Homo sapiens | |
additional information | indirubin-3'-monoxime is no inhibitor of MAPK2/ERK2 | Mus musculus | |
purvalanol | 16% inhibition at 0.01 mM of JNK/SAPK1c, no inhibition of SAPK2a/p38, SAPK3/p38gamma, and SAPK4/p38delta | Homo sapiens | |
purvalanol | 74% inhibition of MAPK2/ERK2 at 0.01 mM | Mus musculus | |
roscovitine | 19% inhibition of MAPK2/ERK2 at 0.01 mM | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
ERK2 | - |
Mus musculus |
JNK/SAPK1c | - |
Homo sapiens |
MAPK2 | - |
Mus musculus |
SAPK2a/p38 | - |
Homo sapiens |
SAPK2b/p38beta | - |
Homo sapiens |
SAPK3/p38gamma | - |
Homo sapiens |
SAPK4/p38delta | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
21 | - |
assay at room temperature | Mus musculus |
21 | - |
assay at room temperature | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |