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Literature summary for 2.7.11.24 extracted from

  • Adams Joseph, A.
    Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model? (2003), Biochemistry, 42, 601-607.
    View publication on PubMed
Search for more literature for 2.7.11.24

Activating Compound

Activating Compound Comment Organism Structure
additional information phosphorylation activates the enzyme eukaryota

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein eukaryota
-
 ADP + a phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is regulated by reversible phosphorylation of the activation loop, phosphorylation enhances the substrate binding of ERK2 by 2fold eukaryota

Reaction

Reaction Comment Organism Reaction ID
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate activation involves the activation loop, a polypeptide region outside the active site cleft, which is reversibly phosphorylated eukaryota
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
ERK2
-
 eukaryota
extracellular regulated kinase-2
-
 eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP the binding site is a deep pocket lined by hydrophobic residues, enzyme affinity for ATP is slightly increased by phosphorylation of the activation loop eukaryota