Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bicuculline | elevation of eEF2K activity with bicuculline, a GABA receptor antagonist | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JAN-384 | a JAN-384 highly selective eEF2K inhibitor, comparison to inhibition of other protein kinases | Mus musculus | |
JAN-452 | slight inhibition | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Mus musculus | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus | |
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Mus musculus | phosphorylation at Thr56 | ADP + [elongation factor 2] phosphate | - |
? | |
ATP + [elongation factor 2] | Mus musculus C57/BL6J | phosphorylation at Thr56 | ADP + [elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O08796 | - |
- |
Mus musculus C57/BL6J | O08796 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | primary cortical neurons | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | phosphorylation at Thr56 | Mus musculus | ADP + [elongation factor 2] phosphate | - |
? | |
ATP + [elongation factor 2] | phosphorylation at Thr56 | Mus musculus C57/BL6J | ADP + [elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2K | - |
Mus musculus |
eukaryotic elongation factor 2 kinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000005 | - |
pH and temperature not specified in the publication | Mus musculus | JAN-384 | |
0.03 | - |
pH and temperature not specified in the publication | Mus musculus | JAN-452 |
General Information | Comment | Organism |
---|---|---|
malfunction | processes related to microtubules are particularly sensitive to eEF2K inhibition | Mus musculus |
physiological function | eEF2K likely contributes to neuronal function by regulating the synthesis of microtubule-related proteins. Phosphorylation of elongation factor 2, EF2, results in slower elongation which then result in the increased synthesis of specific proteins. Expression levels of eEF2K targets with unaltered, enhanced, and reduced eEF2K enzyme activity, overview. Synthesis of MAP1B, ARC, and CAMKIIa is sensitive to eEF2K inhibition | Mus musculus |