Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Rosetta (DE3) cells | Mus musculus |
expressed in Escherichia coli Rosetta (DE3) cells | Saccharomyces cerevisiae |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 0.1 M Bis-Tris (pH 5.5) and 21-28% (w/v) polyethylene glycol 2000 | Mus musculus |
hanging drop vapor diffusion method, using 0.1 M Bis-Tris (pH 5.5) and 21-28% (w/v) polyethylene glycol 2000 | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation initiation factor 2] | Mus musculus | - |
ADP + [eukaryotic translation initiation factor 2]phosphate | - |
? | |
ATP + [eukaryotic translation initiation factor 2] | Saccharomyces cerevisiae | - |
ADP + [eukaryotic translation initiation factor 2]phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9QZ05 | - |
- |
Saccharomyces cerevisiae | P15442 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Superdex 75 gel filtration | Mus musculus |
Ni-NTA column chromatography and Superdex 75 gel filtration | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [eukaryotic translation initiation factor 2] | - |
Mus musculus | ADP + [eukaryotic translation initiation factor 2]phosphate | - |
? | |
ATP + [eukaryotic translation initiation factor 2] | - |
Saccharomyces cerevisiae | ADP + [eukaryotic translation initiation factor 2]phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | x-ray crystallography | Mus musculus |
homodimer | x-ray crystallography | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
GCN2 | - |
Mus musculus |
GCN2 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | in response to amino acid starvation, GCN2 phosphorylation of eukaryotic initiation factor 2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress | Mus musculus |
physiological function | in response to amino acid starvation, GCN2 phosphorylation of eukaryotic initiation factor 2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress | Saccharomyces cerevisiae |