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Literature summary for 2.7.11.20 extracted from

  • He, H.; Singh, I.; Wek, S.; Dey, S.; Baird, T.; Wek, R.; Georgiadis, M.
    Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals (2014), J. Biol. Chem., 289, 15023-15034.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta (DE3) cells Mus musculus
expressed in Escherichia coli Rosetta (DE3) cells Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 0.1 M Bis-Tris (pH 5.5) and 21-28% (w/v) polyethylene glycol 2000 Mus musculus
hanging drop vapor diffusion method, using 0.1 M Bis-Tris (pH 5.5) and 21-28% (w/v) polyethylene glycol 2000 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [eukaryotic translation initiation factor 2] Mus musculus
-
ADP + [eukaryotic translation initiation factor 2]phosphate
-
?
ATP + [eukaryotic translation initiation factor 2] Saccharomyces cerevisiae
-
ADP + [eukaryotic translation initiation factor 2]phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QZ05
-
-
Saccharomyces cerevisiae P15442
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and Superdex 75 gel filtration Mus musculus
Ni-NTA column chromatography and Superdex 75 gel filtration Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [eukaryotic translation initiation factor 2]
-
Mus musculus ADP + [eukaryotic translation initiation factor 2]phosphate
-
?
ATP + [eukaryotic translation initiation factor 2]
-
Saccharomyces cerevisiae ADP + [eukaryotic translation initiation factor 2]phosphate
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Mus musculus
homodimer x-ray crystallography Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
GCN2
-
Mus musculus
GCN2
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function in response to amino acid starvation, GCN2 phosphorylation of eukaryotic initiation factor 2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress Mus musculus
physiological function in response to amino acid starvation, GCN2 phosphorylation of eukaryotic initiation factor 2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress Saccharomyces cerevisiae