Protein Variants | Comment | Organism |
---|---|---|
S398A | phosphorylation-defective mutant, mutation results in an increased stability under normal culture conditions, t1/2 is above 24 h | Homo sapiens |
S78A/S366A | phosphorylation-defective mutant, mutation results in an increased stability under normal culture conditions, t1/2 is above 24 h | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Ca2+/calmodulin-dependent enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Homo sapiens | - |
ADP + [elongation factor 2] phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of the enzyme differentially affects the turnover of the enzyme under both normal and stress conditions. Phosphorylation control of the enzyme is a complex process, with a variety of signaling pathways converging on eEF-2K. The mTOR pathway deactivates the enzyme by phosphorylating the enzyme at Ser78 and Ser366, while the AMPK pathway activates eEF-2K through phosphorylation at Ser398 during cellular stress | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell line | T98G and LN299 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | - |
Homo sapiens | ADP + [elongation factor 2] phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EEF-2K | - |
Homo sapiens |
elongation factor-2 kinase | - |
Homo sapiens |