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Literature summary for 2.7.11.20 extracted from

  • Smith, E.M.; Proud, C.G.
    Cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner (2008), EMBO J., 27, 1005-1016.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
calcium/calmodulin dependent on Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation at Ser359 by cyclin-dependent kinase 1, as cdc2-cyclin B complex, inhibits eEF2K activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
calcium/calmodulin dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the calcium/calmodulin-dependent kinase phosphorylates and inactivates eukaryotic elongation factor 2 and is subject to multisite phosphorylation, which regulates its activity. Phosphorylation at Ser359 by cyclin-dependent kinase 1, as cdc2–cyclin B complexe, inactivates the enzyme occuring early in mitosis probably to keep the elongation factor 2 active during mitosis, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00418
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the calcium/calmodulin-dependent kinase, that phosphorylates and inactivates eukaryotic elongation factor 2, is subject to multisite phosphorylation, which regulates its activity, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the calcium/calmodulin-dependent kinase phosphorylates and inactivates eukaryotic elongation factor 2 and is subject to multisite phosphorylation, which regulates its activity. Phosphorylation at Ser359 by cyclin-dependent kinase 1, as cdc2–cyclin B complexe, inactivates the enzyme occuring early in mitosis probably to keep the elongation factor 2 active during mitosis, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
eEF2 kinase
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Homo sapiens
eEF2K
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Homo sapiens