Literature summary for 2.7.11.20 extracted from

Hong-Brown, L.Q.; Brown, C.R.; Huber, D.S.; Lang, C.H.
Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes (2007), J. Biol. Chem., 282, 3702-3712.

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Activating Compound

Activating Compound	Comment	Organism	Structure
AICAR	increases the levels of eEF2K phosphorylation more than 2fold	Mus musculus
FBS protein	increases the levels of eEF2K phosphorylation more than 2fold	Mus musculus

Application

Application	Comment	Organism
additional information	eEF2 kinase does not play a role in regulating elongation factor 2	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
ethanol	decreases phosphorylation of eEF2K, whereas elongation factor 2 phosphorylation increases, but this response is not mediated by eEF2K	Mus musculus
rottlerin	blocks the effects of stimulators AICAR and FBS	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [elongation factor 2]	-	Mus musculus	ADP + [elongation factor 2]phosphate	-	?

Synonyms

Synonyms	Comment	Organism
eEF2 kinase	-	Mus musculus
eEF2K	-	Mus musculus

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Release 2023.1 (January 2023)