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Literature summary for 2.7.11.20 extracted from

  • Rose, A.J.; Broholm, C.; Kiillerich, K.; Finn, S.G.; Proud, C.G.; Rider, M.H.; Richter, E.A.; Kiens, B.
    Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men (2005), J. Physiol., 569, 223-228.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin strong activation, activation in response to exercise in skeletal muscle Homo sapiens
additional information 90 min continuous exercise rapidly increases eukaryotic elongation factor 2 phosphorylation 5-7fold within 1 minute in skeletal muscle of male humans, activation does not function by covalent mechanisms but by allosteric mechanisms involving Ca2+ signaling via calmodulin Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ strong activation, activation in response to exercise in skeletal muscle Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [elongation factor 2] Homo sapiens phosphorylation at Thr56 ADP + [elongation factor 2]phosphate
-
?
additional information Homo sapiens the enzyme regulates protein synthesis in skeletal muscle ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
male humans of about 25 years
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [elongation factor 2] phosphorylation at Thr56 Homo sapiens ADP + [elongation factor 2]phosphate
-
?
additional information the enzyme regulates protein synthesis in skeletal muscle Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
eEF2 kinase
-
Homo sapiens
eukaryotic elongation factor 2 kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens