Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | strong activation, activation in response to exercise in skeletal muscle | Homo sapiens | |
additional information | 90 min continuous exercise rapidly increases eukaryotic elongation factor 2 phosphorylation 5-7fold within 1 minute in skeletal muscle of male humans, activation does not function by covalent mechanisms but by allosteric mechanisms involving Ca2+ signaling via calmodulin | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | strong activation, activation in response to exercise in skeletal muscle | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | Homo sapiens | phosphorylation at Thr56 | ADP + [elongation factor 2]phosphate | - |
? | |
additional information | Homo sapiens | the enzyme regulates protein synthesis in skeletal muscle | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
male humans of about 25 years | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [elongation factor 2] | phosphorylation at Thr56 | Homo sapiens | ADP + [elongation factor 2]phosphate | - |
? | |
additional information | the enzyme regulates protein synthesis in skeletal muscle | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
eEF2 kinase | - |
Homo sapiens |
eukaryotic elongation factor 2 kinase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |