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Literature summary for 2.7.11.2 extracted from

  • Rahman, M.H.; Jha, M.K.; Kim, J.H.; Nam, Y.; Lee, M.G.; Go, Y.; Harris, R.A.; Park, D.H.; Kook, H.; Lee, I.K.; Suk, K.
    Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy (2016), J. Biol. Chem., 291, 6011-6025.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.2

Organism

Organism UniProt Comment Textmining
Mus musculus O70571
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Mus musculus Q9JK42
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-

Source Tissue

Source Tissue Comment Organism Textmining
dorsal root ganglion
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 Mus musculus
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neuron
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 Mus musculus
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Synonyms

Synonyms Comment Organism
PDK2 isoform Mus musculus
PDK4 isoform Mus musculus
pyruvate dehydrogenase kinase
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 Mus musculus

General Information

General Information Comment Organism
physiological function isoform PDK2 up-regulation in the diabetic dorsal root ganglion plays a critical role in inducing peripheral as well as central sensitizations, eventually causing diabetic neuropathic pain Mus musculus
physiological function isoform PDK4 up-regulation in the diabetic dorsal root ganglion plays a critical role in inducing peripheral as well as central sensitizations, eventually causing diabetic neuropathic pain Mus musculus