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Literature summary for 2.7.11.2 extracted from

  • Piao, L.; Sidhu, V.K.; Fang, Y.H.; Ryan, J.J.; Parikh, K.S.; Hong, Z.; Toth, P.T.; Morrow, E.; Kutty, S.; Lopaschuk, G.D.; Archer, S.L.
    FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate (2013), J. Mol. Med., 91, 333-346.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.2

Inhibitors

Inhibitors Comment Organism Structure
Dichloroacetate the PDK inhibitor restores pyruvate dehydrogenae activity and enhances glucose oxidation with beneficial molecular effects, i.e. downregulation of FOXO-1 and PDK4, and functional improvement,i.e. enhanced right ventricular function and exercise capacity Homo sapiens
Dichloroacetate the PDK inhibitor restores pyruvate dehydrogenae activity and enhances glucose oxidation with beneficial molecular effects, i.e. downregulation of FOXO-1 and PDK4, and functional improvement,i.e. enhanced right ventricular function and exercise capacity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Rattus norvegicus Fawn-Hooded
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
heart
-
 Rattus norvegicus
-
lung
-
 Homo sapiens
-
lung
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PDK4
-
 Homo sapiens
PDK4
-
 Rattus norvegicus
pyruvate dehydrogenase kinase-4
-
 Homo sapiens
pyruvate dehydrogenase kinase-4
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens FOXO1-mediated 4fold upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation up
Rattus norvegicus FOXO1-mediated 4fold upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation up

General Information

General Information Comment Organism
malfunction FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension, overview. The bioenergetic impairment and right ventricular dysfunction can be reversed by dichloroacetate Homo sapiens
malfunction FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension, overview. The bioenergetic impairment and right ventricular dysfunction can be reversed by dichloroacetate Rattus norvegicus
physiological function expression of PDK4 is regulated by its regulatory transcription factor, FOXO1. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation Homo sapiens
physiological function expression of PDK4 is regulated by its regulatory transcription factor, FOXO1. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation Rattus norvegicus