Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dichloroacetate | the PDK inhibitor restores pyruvate dehydrogenae activity and enhances glucose oxidation with beneficial molecular effects, i.e. downregulation of FOXO-1 and PDK4, and functional improvement,i.e. enhanced right ventricular function and exercise capacity | Homo sapiens | |
Dichloroacetate | the PDK inhibitor restores pyruvate dehydrogenae activity and enhances glucose oxidation with beneficial molecular effects, i.e. downregulation of FOXO-1 and PDK4, and functional improvement,i.e. enhanced right ventricular function and exercise capacity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Fawn-Hooded | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PDK4 | - |
Homo sapiens |
PDK4 | - |
Rattus norvegicus |
pyruvate dehydrogenase kinase-4 | - |
Homo sapiens |
pyruvate dehydrogenase kinase-4 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | FOXO1-mediated 4fold upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation | up |
Rattus norvegicus | FOXO1-mediated 4fold upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension, overview. The bioenergetic impairment and right ventricular dysfunction can be reversed by dichloroacetate | Homo sapiens |
malfunction | FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension, overview. The bioenergetic impairment and right ventricular dysfunction can be reversed by dichloroacetate | Rattus norvegicus |
physiological function | expression of PDK4 is regulated by its regulatory transcription factor, FOXO1. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation | Homo sapiens |
physiological function | expression of PDK4 is regulated by its regulatory transcription factor, FOXO1. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4. Pyruvate dehydrogenase kinase is activated in right ventricular hypertrophy, causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. Chronic dichloroacetate inhibits FOXO1-induced PDK4 upregulation and restores gluccoe oxidation | Rattus norvegicus |