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Literature summary for 2.7.11.2 extracted from
- Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid beta and other toxins by decreasing mitochondrial respiration and reactive oxygen species production (2012), J. Biol. Chem., 287, 37245-37258.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Pdk1 | Rattus norvegicus |
| overexpression of either PDK1 in rat CNS cell line B12 confers resistance to amyloid-beta peptide and other neurotoxins | Mus musculus |
| overexpression of PDK1 in the rat CNS cell line B12 confers resistance to amyloid-beta peptide and other neurotoxins. Cells expressing PDK1 maintain a lower mitochondrial membrane potential and decreased ROS production with or without exposure to toxins | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | stable knockdown of PDK1 in B12 cells by transfection with HuSH 29-mer shRNA | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
gene Pdk1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-12 cell | - |
Rattus norvegicus | - |
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| brain | post-mortem brain extracts from patients with Alzheimer disease exhibit a decrease in PDK1 expression compared with nondemented patients | Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
| neuron | - |
Rattus norvegicus | - |
| neuron | primary cortical neurons | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDK1 | - |
Mus musculus |
| PDK1 | - |
Homo sapiens |
| PDK1 | - |
Rattus norvegicus |
| pyruvate dehydrogenase kinase 1 | - |
Mus musculus |
| pyruvate dehydrogenase kinase 1 | - |
Homo sapiens |
| pyruvate dehydrogenase kinase 1 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens |  |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | post-mortem brain extracts from patients with Alzheimer disease exhibit a decrease in PDK1 expression compared with nondemented patients | down |
| Homo sapiens | HIF-1alpha is a heterodimeric transcription factor that regulates cellular adaptation to hypoxia and induces the transcription of pyruvate dehydrogenase kinase 1 | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | wild-type mouse primary cortical neurons treated with amyloid beta peptide or cortical tissue extracts from 12-month-old APPswe/PS1dE9 transgenic mice show decreased expression of lactate dehydrogenase A and PDK1 when compared with controls | Mus musculus |
| malfunction | wild-type mouse primary cortical neurons treated with amyloid beta peptide or cortical tissue extracts from 12-month-old APPswe/PS1dE9 transgenic mice show decreased expression of lactate dehydrogenase A and PDK1 when compared with controls | Rattus norvegicus |
| additional information | overexpression of lactate dehydrogenase A or PDK1 in the B12 central nervous system cell line confers resistance to amyloid beta, H2O2, and staurosporine. Increased survival in cells overexpressing lactate dehydrogenase A or PDK1, associated with decreased mitochondrial membrane potential | Homo sapiens |
| additional information | overexpression of lactate dehydrogenase A or PDK1 in the B12 central nervous system cell line confers resistance to amyloid beta, H2O2, and staurosporine. Increased survival in cells overexpressing lactate dehydrogenase A or PDK1. Increased survival in cells overexpressing LDHA or PDK1 is associated with decreased mitochondrial membrane potential | Rattus norvegicus |
| physiological function | PDK1 phosphorylates and inhibits pyruvate dehydrogenase, an enzyme responsible for the conversion of pyruvate to acetyl-CoA | Mus musculus |
| physiological function | PDK1 phosphorylates and inhibits pyruvate dehydrogenase, an enzyme responsible for the conversion of pyruvate to acetyl-CoA | Homo sapiens |
| physiological function | PDK1 phosphorylates and inhibits pyruvate dehydrogenase, an enzyme responsible for the conversion of pyruvate to acetyl-CoA | Rattus norvegicus |
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