Cloned (Comment) | Organism |
---|---|
expression of PDHK2 in HEK293 cells as FLAG-tagged proteins and under a tetracycline-inducible system | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
C195A | site-directed mutagenesis | Rattus norvegicus |
C212A | site-directed mutagenesis | Rattus norvegicus |
C395A | site-directed mutagenesis | Rattus norvegicus |
C45A | site-directed mutagenesis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dichloroacetate | - |
Rattus norvegicus | |
H2O2 | PDHK2 activity is inhibited by low levels of hydrogen peroxide generated by the respiratory chain via reversible oxidation of Cys45 and Cys392 on PDHK2 | Rattus norvegicus | |
menadione | PDHK2 activity is inhibited via reversible oxidation of Cys45 and Cys392 on PDHK2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
dimeric enzyme, an intermolecular disulfide between two Cys-392 residues is present, in wild-type enzyme and mutant C45A | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Rattus norvegicus |
monomer | - |
Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PDHK2 | - |
Rattus norvegicus |
pyruvate dehydrogenase kinase 2 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition results in increased pyruvate dehydrogenase complex activity. Oxidation of Cys45 or Cys392 inhibits PDHK2 activity. Dimer formation is not essential for PDHK2 inactivation via Cys392 oxidation, although it may potentiate it | Rattus norvegicus |
metabolism | PDHK2 is responsible for short-term metabolic responses | Rattus norvegicus |