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Literature summary for 2.7.11.2 extracted from

  • Kwon, H.; Huang, B.; Jeoung, N.H.; Wu, P.; Steussy, C.N.; Harris, R.A.
    Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression (2006), Biochim. Biophys. Acta, 1759, 141-151.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information PDK4 expression is induced by retinoic acids and trichostatin A Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
PDK4, expression of PDK2 and PDK4 in 29T cells, transient expression of PDK4 and PDK4 promoter in CV-1 cells, expression is regulated by retinoic acids and trichostatin A, the proximal promoter contains two retinoic acid response elements binding retinoid X receptor alpha and retinoid acid receptor alpha leading to transcriptional activation, the PDK4 expression activation by all components is prevented by interaction of p300/CBP with E1A, expression analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PDK4 expression is specifically regulated by retinoic acids, via retinoid receptors, and trichostatin A, an inhibitor of histone deacetylase ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme PDK4
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDK4 expression is specifically regulated by retinoic acids, via retinoid receptors, and trichostatin A, an inhibitor of histone deacetylase Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PDK
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Homo sapiens
pyruvate dehydrogenase kinase
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Homo sapiens