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Literature summary for 2.7.11.2 extracted from

  • Koukourakis, M.I.; Giatromanolaki, A.; Sivridis, E.; Gatter, K.C.; Harris, A.L.
    Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma (2005), Neoplasia, 7, 1-6.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate dehydrogenase Homo sapiens
-
 ADP + phosphorylated pyruvate dehydrogenase
-
 ?
additional information Homo sapiens the PDK/PDH pathway is reduced by 73% in non small cell lung carcinoma contributing to hypoxia-inducible factor-1 stability and aerobic glycolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell high PDK expression Homo sapiens
-
fibroblast in the non small cell lung tumor-supporting stroma, reduced expression of PDK1, high PDH activity Homo sapiens
-
lung PDK1 and PDH expression patterns Homo sapiens
-
non-small cell lung cancer cell i.e. NSCLC, reduced PDK/PDH activity, PDK1 and PDH expression patterns Homo sapiens
-
squamous cell carcinoma cell high PDK expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate dehydrogenase
-
 Homo sapiens ADP + phosphorylated pyruvate dehydrogenase
-
 ?
additional information the PDK/PDH pathway is reduced by 73% in non small cell lung carcinoma contributing to hypoxia-inducible factor-1 stability and aerobic glycolysis Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More PDK is a component of the pyruvate dehydrogenase complex Homo sapiens

Synonyms

Synonyms Comment Organism
PDK
-
 Homo sapiens
PDK1
-
 Homo sapiens
pyruvate dehydrogenase kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens