Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PDK4 expression is induced by hepatic nuclear factor 4, HNF4, determination of binding sites on the PDK4 promoter | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis of the PDK4 gene promoter, analysis of transcriptional activation mechanism, expression analysis, overview, transient expression of PDK4 promoter mutants in hepatocytes | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of PDK4 gene promoter deletion and point mutants for functional analysis, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate dehydrogenase | Rattus norvegicus | phosphorylation by PDK inhibits the pyruvate dehydrogenase complex, PDK plays a regulatory role in glucose metabolism, PDK4 expression is regulated by hepatic nuclear factor 4 and peroxisome proliferator-activated receptor gamma coactivator, PGC-1alpha | ADP + phosphorylated pyruvate dehydrogenase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
myocyte | cardiac | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pyruvate dehydrogenase | - |
Rattus norvegicus | ADP + phosphorylated pyruvate dehydrogenase | - |
? | |
ATP + pyruvate dehydrogenase | phosphorylation by PDK inhibits the pyruvate dehydrogenase complex, PDK plays a regulatory role in glucose metabolism, PDK4 expression is regulated by hepatic nuclear factor 4 and peroxisome proliferator-activated receptor gamma coactivator, PGC-1alpha | Rattus norvegicus | ADP + phosphorylated pyruvate dehydrogenase | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDK4 | - |
Rattus norvegicus |
pyruvate dehydrogenase kinase 4 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |