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Literature summary for 2.7.11.2 extracted from
- Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase (2003), J. Biol. Chem., 278, 33681-33693.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | pyruvate dehydrogenase complex components interaction dissociation constants and kinetics | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
| Na+ | hinders interaction between PDK2 and the inner lipoyl domain L2 | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
sedimentation equilibrium centrifugation analysis of the pyruvate dehydrogenase complex and components | Homo sapiens |
| 45816 | - |
2 * 45816, sedimentation equilibrium centrifugation analysis in presence of 1% ethylene glycol, 0.1% Pluronics F68, and 0.15 M NaCl | Homo sapiens |
| 90220 | - |
isozyme PDK2, sedimentation equilibrium centrifugation analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | pyruvate dehydrogenase kinase is part of the pyruvate dehydrogenase complex, regulation and component interactions, PDK2 binds the inner lipoyl domain L2, preferably in dimeric form, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozyme PDK2 | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.1 | - |
purified isozyme PDK2 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | pyruvate dehydrogenase kinase is part of the pyruvate dehydrogenase complex, regulation and component interactions, PDK2 binds the inner lipoyl domain L2, preferably in dimeric form, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 45816, sedimentation equilibrium centrifugation analysis in presence of 1% ethylene glycol, 0.1% Pluronics F68, and 0.15 M NaCl | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDK2 | - |
Homo sapiens |
| pyruvate dehydrogenase kinase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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