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Literature summary for 2.7.11.2 extracted from

  • Sugden, M.C.; Langdown, M.L.; Harris, R.A.; Holness, M.J.
    Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply (2000), Biochem. J., 352, 731-738.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.2

Activating Compound

Activating Compound Comment Organism Structure
Lipid selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus
Thyroid hormones selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
pyruvate isozyme PDHK4 is less sensitive than PDHK1 and PDHK2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus enzyme regulation in the heart depends on thyroid hormone and lipid status ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus enzyme regulates glucose oxidation by pyruvate dehydrogenase complex, isozyme PDHK1 is of more potential importance in adult heart than the other isozymes ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Wistar rats
-
Rattus norvegicus
-
 selective increase in amount of PDHK4 protein in both hyperthyroidism and high-fat feeding
-
Rattus norvegicus
-
 3 isozymes PDHK1, PDHK2, PDHK4
-

Source Tissue

Source Tissue Comment Organism Textmining
heart developing and adult heart, the latter contains 3 isozymes: PDHK1, PDHK2 and PDHK4, clear differences in protein expression patterns of the isoforms dependent on developmental stage, overview Rattus norvegicus
-
additional information selective increase in amount of isozyme PDHK4 protein in both hyperthyroidism and high-fat feeding Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] enzyme regulation in the heart depends on thyroid hormone and lipid status Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] enzyme regulates glucose oxidation by pyruvate dehydrogenase complex, isozyme PDHK1 is of more potential importance in adult heart than the other isozymes Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Synonyms

Synonyms Comment Organism
PDH kinase
-
 Rattus norvegicus
PDHK
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.4 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus