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Literature summary for 2.7.11.2 extracted from

  • Ravindran, S.; Radke, G.A.; Guest, J.R.; Roche, T.E.
    Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity (1996), J. Biol. Chem., 271, 653-662.
    View publication on PubMed
Search for more literature for 2.7.11.2

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
acetyl-CoA high stimulation through acetylation of the transacetylase-catalyzing inner core portion of the dihydrolipoyl acetyltransferase Bos taurus
dihydrolipoyl transacetylase involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
dihydrolipoyl transacetylase binding and activation mechanism Bos taurus
NADH involved in the regulation of enzyme activity regulating pyruvate dehydrogenase complex Bos taurus
pyruvate at low concentration, with the thiamine diphosphate containing pyruvate dehydrogenase complex, stimulation mechanism Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
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 ir

Organism

Organism UniProt Comment Textmining
Bos taurus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] incorporates gamma-phosphate from ATP into E1-component of pyruvate dehydrogenase-complex alpha-subunit Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
 ir

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Bos taurus