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Literature summary for 2.7.11.2 extracted from

  • Pratt, T.E.; Roche, T.E.
    Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenase kinase and synergistic inhibition by pyruvate and ADP (1979), J. Biol. Chem., 254, 7191-7196.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dichloroacetate noncompetitive; pyruvate analog, synergism with ADP, K+ or phosphate, kinetics Bos taurus
HPO42- enhances inhibition by pyruvate or dichloroacetate Bos taurus
K+ pyruvate or dichloroacetate Bos taurus
pyruvate kinetics; noncompetitive to ATP; synergism with ADP; synergism with K+ or phosphate Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
ATP
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate mechanism Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.27
-
pyruvate pH 7.2, 30°C Bos taurus
0.27
-
Dichloroacetate pH 7.2, 30°C Bos taurus
0.27
-
pyruvate kinetic constant from binding study Bos taurus
0.27
-
Dichloroacetate kinetic constant from binding study Bos taurus