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BRENDA support

Literature summary for 2.7.11.2 extracted from

  • Sheu, K.F.R.; Lai, J.C.K.; Blass, J.P.
    Properties and regional distribution of pyruvate dehydrogenase kinase in rat brain (1984), J. Neurochem., 42, 230-236.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dichloroacetate
-
Rattus norvegicus
pyruvate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
divalent cations requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Rattus norvegicus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain higher activity in cerebral cortex and hippocampus than in hypothalamus, pons, medulla and olfactory bulbs Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-
hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Rattus norvegicus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Rattus norvegicus