Literature summary for 2.7.11.19 extracted from

Camus, S.; Quevedo, C.; Menendez, S.; Paramonov, I.; Stouten, P.F.; Janssen, R.A.; Rueb, S.; He, S.; Snaar-Jagalska, B.E.; Laricchia-Robbio, L.; Izpisua Belmonte, J.C.
Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish (2012), Oncogene, 31, 4333-4342.

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Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
PhKG1	phosphorylase kinase subunit G1	Homo sapiens
PhKG1	phosphorylase kinase subunit G1	Danio rerio

Expression

Organism	Comment	Expression
Homo sapiens	PhKG1 is upregulated in human tumor samples from a range of tumor types. PhKG1 mRNA levels are elevated by more than 2fold in the majority of human tumors tested, no upregulation of PhKG1 is detected in prostate cancer	up
Danio rerio	PhKG1 is upregulated in human tumor samples from a range of tumor types. PhKG1 mRNA levels are elevated by more than 2fold in the majority of human tumors tested, no upregulation of PhKG1 is detected in prostate cancer	up

General Information

General Information	Comment	Organism
malfunction	PhKG1 knockdown reduces human umbilical vein endothelial cell tube formation and migration	Homo sapiens
malfunction	PhKG1a knockdown inhibits angiogenic intersegmental vessels formation	Danio rerio
physiological function	phosphorylase kinase subunit G1 (PhKG1) is implicated in angiogenesis	Homo sapiens
physiological function	phosphorylase kinase subunit G1 (PhKG1) is implicated in angiogenesis	Danio rerio

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Release 2023.1 (January 2023)