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Literature summary for 2.7.11.19 extracted from

  • Liu, W.; Priddy, T.S.; Carlson, G.M.
    Physicochemical changes in phosphorylase kinase associated with its activation (2008), Protein Sci., 17, 2111-2119.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required, binds to the delta subunit Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17700
-
alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 17700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits Oryctolagus cuniculus
44700
-
alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 17700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits Oryctolagus cuniculus
125200
-
alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 17700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits Oryctolagus cuniculus
138400
-
alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 17700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycogen phosphorylase b + ATP Oryctolagus cuniculus regulates energy production through its Ca2+-dependent activation of glycogen phosphorylase in the cascade activation of glycogenolysis, only known kinase that activates glycogen phosphorylase b glycogen phosphorylase a + ADP
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
New Zealand white rabbit
-

Purification (Commentary)

Purification (Comment) Organism
-
Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen phosphorylase b + ATP regulates energy production through its Ca2+-dependent activation of glycogen phosphorylase in the cascade activation of glycogenolysis, only known kinase that activates glycogen phosphorylase b Oryctolagus cuniculus glycogen phosphorylase a + ADP
-
?

Subunits

Subunits Comment Organism
hexadecamer alpha,beta, gamma,delta, 4 * 138400 + 4 * 125200 + 4 * 44700 + 4 * 17700, catalytic gamma subunit is controlled by its regulatory alpha and beta, and delta subunits Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Oryctolagus cuniculus
PhK
-
Oryctolagus cuniculus

pH Range

pH Minimum pH Maximum Comment Organism
6.8 8.2 activity increases dramatically when the pH is raised from 6.8 to 8.2 Oryctolagus cuniculus