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Literature summary for 2.7.11.19 extracted from

  • Priddy, T.S.; Middaugh, C.R.; Carlson, G.M.
    Electrostatic changes in phosphorylase kinase induced by its obligatory allosteric activator Ca2+ (2007), Protein Sci., 16, 517-527.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.19

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ is an obligatory allosteric activator absolutely required by the enzyme, Ca2+ activates PhK by binding to its nondissociable calmodulin subunits, it couples the cascade activation of glycogenolysis with muscle contraction, enzyme surface electrostatic properties of solvent accessible charged and polar groups are altered upon the binding of Ca2+ ions Oryctolagus cuniculus
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycogen phosphorylase b Oryctolagus cuniculus
-
 ADP + phosphorylated glycogen phosphorylase b
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Source Tissue

Source Tissue Comment Organism Textmining
psoas
-
 Oryctolagus cuniculus
-
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen phosphorylase b
-
 Oryctolagus cuniculus ADP + phosphorylated glycogen phosphorylase b
-
 ?
ATP + glycogen phosphorylase b the hexadecameric enzyme complex that catalyzes the phosphorylation and activation of glycogen phosphorylase b Oryctolagus cuniculus ADP + phosphorylated glycogen phosphorylase b
-
 ?

Subunits

Subunits Comment Organism
hexadecamer tertiary and secondary structure of PhK measured in presence or absence of Ca2+, conformational changes induced by Ca2+, surface electrostatic properties of solvent accessible charged and polar groups are altered upon the binding of Ca2+ ions, overview Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
PhK
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
additional information
-
 reaction and conformation temperature dependence, overview Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus