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Literature summary for 2.7.11.19 extracted from

  • Hilder, T.L.; Carlson, G.M.; Haystead, T.A.; Krebs, E.G.; Graves, L.M.
    Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase (2005), Mol. Cell. Biochem., 275, 233-242.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
caspase-3 selective in vitro cleavage of the regulatory alpha-subunit increasing the enzyme activity 2fold Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information after treatment of differentiated C2C12 muscle myoblasts with apoptosis inducers staurosporine, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine, doxorubicin, or UV radiation the enzyme alpha-subunit disappears Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Oryctolagus cuniculus
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycogen phosphorylase b Mus musculus key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview ADP + glycogen phosphorylase a
-
 ?
ATP + glycogen phosphorylase b Oryctolagus cuniculus key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview ADP + glycogen phosphorylase a
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification specific cleavage of caspase-3 at a specific cleavage site within the alpha-subunit at residue 46 in the sequence DWMD*G Oryctolagus cuniculus
proteolytic modification specific cleavage of caspase-3 at a specific cleavage site within the alpha-subunit in vivo Mus musculus

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell differentiated muscle myoblasts Mus musculus
-
myoblast muscle cells Mus musculus
-
skeletal muscle
-
 Mus musculus
-
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen phosphorylase b
-
 Mus musculus ADP + glycogen phosphorylase a
-
 ?
ATP + glycogen phosphorylase b
-
 Oryctolagus cuniculus ADP + glycogen phosphorylase a
-
 ?
ATP + glycogen phosphorylase b key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview Mus musculus ADP + glycogen phosphorylase a
-
 ?
ATP + glycogen phosphorylase b key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview Oryctolagus cuniculus ADP + glycogen phosphorylase a
-
 ?

Subunits

Subunits Comment Organism
hexadecamer (alphabetagammadelta)4 Oryctolagus cuniculus
More calmodulin is identical with the delta subunit Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
PhK
-
 Mus musculus
PhK
-
 Oryctolagus cuniculus
Phosphorylase b kinase
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Oryctolagus cuniculus
Calmodulin identical with the delta subunit Mus musculus
Calmodulin identical with the delta subunit Oryctolagus cuniculus