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Literature summary for 2.7.11.19 extracted from
- A theoretical study of effects of cytosolic Ca2+ oscillations on activation of glycogen phosphorylase (2003), Biophys. Chem., 106, 193-202.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | Ca2+-sensitivity of the enzyme is mediated by the delta-subunit which is identical with calmodulin | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + glycogen phosphorylase b | Homo sapiens | activation of glycogen phosphorylase which acts as a Ca2+-dependent blood glucose sensor liberating glucose from glycogen as needed, involved in regulation of the glycogen phosphorylase | ADP + glycogen phosphorylase a | - |
? | |
| additional information | Homo sapiens | modeling of glycogen phosphorylase regulation by Ca2+-oscillations, and dephosphorylation and phosphorylation involving the enzyme and a phosphatase, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + glycogen phosphorylase b | - |
Homo sapiens | ADP + glycogen phosphorylase a | - |
? | |
| ATP + glycogen phosphorylase b | activation of glycogen phosphorylase which acts as a Ca2+-dependent blood glucose sensor liberating glucose from glycogen as needed, involved in regulation of the glycogen phosphorylase | Homo sapiens | ADP + glycogen phosphorylase a | - |
? | |
| additional information | modeling of glycogen phosphorylase regulation by Ca2+-oscillations, and dephosphorylation and phosphorylation involving the enzyme and a phosphatase, overview | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexadecamer | alpha4beta4gamma4delta4 | Homo sapiens |
| More | the delta subunit is identical with calmodulin | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| Calmodulin | mediates Ca2+-sensitivity of the enzyme, calmodulin is identical with the delta-subunit | Homo sapiens | |
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Release 2023.1 (January 2023)
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