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Literature summary for 2.7.11.19 extracted from

  • Lanciotti, R.A.; Bender, P.K.
    The gamma subunit of phosphorylase kinase contains a pseudosubstrate sequence (1995), Eur. J. Biochem., 230, 139-145.
    View publication on PubMed
Search for more literature for 2.7.11.19

Inhibitors

Inhibitors Comment Organism Structure
Lys-Pro-Val-Thr-Arg-Glu-Ile-Val-Ile-Arg-NH2 i.e. V-peptide Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic parameters for recombinant wild-type gamma subunit and its mutant form Mus musculus
0.014
-
 phosphorylase b recombinant gamma subunit, pH 6.8 Mus musculus
0.03 0.037 ATP phosphorylase b Mus musculus
0.03 0.037 ATP recombinant gamma subunit, pH 8.2 Mus musculus
0.19
-
 phosphorylase b nonactivated enzyme, pH 8.2 Mus musculus
0.2
-
 ATP Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp, Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp, nonactivated enzyme, pH 8.2 Mus musculus
0.21
-
 S-peptide recombinant gamma subunit, pH 8.2 Mus musculus
0.22
-
 ATP S-peptide, activated enzyme, pH 6.8 Mus musculus
0.28
-
 S-peptide recombinant gamma subunit, pH 6.8 Mus musculus
0.9 1 Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp-Gly-Ile pH 8.2 Mus musculus
1.2
-
 Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp-Gly-Ile nonactivated enzyme, pH 8.2 Mus musculus
2
-
 Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp activated enzyme, pH 8.2 Mus musculus
3.5
-
 Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp-Gly-Ile activated enzyme, pH 8.2 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Mus musculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Mus musculus
phosphate requirement, phosphate containing enzyme Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid sequence in regulatory domain of gamma subunit Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
10.9
-
 truncated form of phosphorylase kinase gamma subunit Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp
-
 Mus musculus ADP + Lys-Arg-Lys-Gln-Ile-(phospho)Ser-Val-Asp
-
 ?
ATP + Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp-Gly-Ile
-
 Mus musculus ADP + Lys-Arg-Lys-Gln-Ile-(phospho)Ser-Val-Asp-Gly-Ile
-
 ?
ATP + Lys-Pro-Val-Thr-Arg-Glu-Ile-Ser-Ile-Arg-NH2 i.e. S-peptide Mus musculus ?
-
 ?
ATP + nonactivated phosphorylase kinase phosphorylation sites Mus musculus ADP + activated phosphorylase kinase
-
 ?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Mus musculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b phosphorylation site: Ser-14 Mus musculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b rabbit skeletal muscle Mus musculus ADP + phosphorylase a
-
 ?
ATP + Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp
-
 Mus musculus ADP + Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-(phospho)Ser-Val-Asp
-
 ?
ATP + Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Asp-Gly-Ile i.e. phosphorylase b peptide (5-18) Mus musculus ADP + Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-(phospho)Ser-Val-Asp-Gly-Ile
-
 ?
ATP + troponin I phosphorylation site Mus musculus ADP + phosphotroponin I
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus