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Literature summary for 2.7.11.19 extracted from

  • Graves, D.J.
    Use of peptide substrates to study the specificity of phosphorylase kinase phosphorylation (1983), Methods Enzymol., 99, 268-278.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Oryctolagus cuniculus
Catalytic subunit of cAMP-dependent protein kinase Mn2+ stimulates Oryctolagus cuniculus
Catalytic subunit of cAMP-dependent protein kinase subunits, in the presence of ATP and Mg2+ Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
(D)-Arg-(D)-Leu-(D)-Ser-(D)-Leu Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Arg-Gly-Leu as substrate Oryctolagus cuniculus
(D)-Leu-(D)-Ser-(D)-Leu-(D)-Arg
-
 Oryctolagus cuniculus
(D)-Leu-(D)-Ser-(D)-Tyr-(D)-Arg-(D)-Arg-(D)-Tyr-(D)-Ser-(D)-Leu
-
 Oryctolagus cuniculus
Arg-Lys-Gln-Ile-Thr-Val-Arg synthetic peptides as substrate Oryctolagus cuniculus
Ile-Ser-Val-Arg-Gly Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Arg-Gly-Leu as substrate Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic data for phosphorylase b Oryctolagus cuniculus
additional information
-
 additional information kinetic data for peptides derived from glycogen synthase Oryctolagus cuniculus
0.2 2.3 peptides from phosphorylase b, synthetic Oryctolagus cuniculus
0.27
-
 phosphorylase b nonactivated enzyme Oryctolagus cuniculus
0.7 3.5 peptides from glycogen synthase, synthetic Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Oryctolagus cuniculus
Mg2+ requirement Oryctolagus cuniculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
Mg2+ required for activity phosphorylation by (cAMP-dependent protein kinase) Oryctolagus cuniculus
Mn2+ activation Oryctolagus cuniculus
Mn2+ stimulates activation by catalytic subunit of cAMP-dependent protein kinase Oryctolagus cuniculus
phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + casein kappa-casein Oryctolagus cuniculus ?
-
 ?
ATP + glycogen synthase
-
 Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
 ?
ATP + histone H1
-
 Oryctolagus cuniculus ?
-
 ?
ATP + nonactivated phosphorylase kinase
-
 Oryctolagus cuniculus ADP + activated phosphorylase kinase
-
 ?
ATP + phosphorylase b
-
 Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b best substrate Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b rabbit skeletal muscle Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b human, rat Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + sarcolemmal protein
-
 Oryctolagus cuniculus ?
-
 ?
ATP + sarcoplasmic protein
-
 Oryctolagus cuniculus ?
-
 ?
ATP + synthetic peptides derived from glycogen synthase overview, phosphorylation at the same site as glycogen synthase Oryctolagus cuniculus ?
-
 ?
ATP + synthetic peptides derived from phosphorylase b overview Oryctolagus cuniculus ?
-
 ?
ATP + synthetic tetradecapeptide i.e. Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Arg-Gly-Leu Oryctolagus cuniculus ?
-
 ?
ATP + troponin I
-
 Oryctolagus cuniculus ADP + phosphotroponin I
-
 ?
ATP + troponin T
-
 Oryctolagus cuniculus ADP + phosphotroponin T
-
 ?
additional information specificity Oryctolagus cuniculus ?
-
 ?
additional information Lys-Gln-Ile-Ser-Val-Arg, Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Gly-Ser-Gly-Arg-Gly-Leu, Lys-Gln-Ile-Thr-Val-Arg, Arg-Lys-Gln-Ile-Thr-Val-Arg are no substrates Oryctolagus cuniculus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Oryctolagus cuniculus