Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Catalytic subunit of cAMP-dependent protein kinase | activation of nonactivated enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EGTA | partial | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activation, 0.0001-0.001 mM, inhibits above 0.001 mM | Rattus norvegicus | |
Mg2+ | requirement | Rattus norvegicus | |
Mg2+ | major role of Mg2+: cosubstrate in Mg2+-ATP complex | Rattus norvegicus | |
Mg2+ | required for activity phosphorylation by (cAMP-dependent protein kinase) | Rattus norvegicus | |
Mg2+ | required for activity and activation (by autophosphorylation) | Rattus norvegicus | |
phosphate | requirement, phosphate containing enzyme | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
1300000 | - |
rat, gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
to near homogeneity from glycogen-rich pellet, from 1000 rats | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.426 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
-70°C, in 20 mM triethanolamine-HCl, pH 7.5, 20% v/v glycerol, 1 mM DTT, 0.02% NaN3, stable | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + casein | very poor substrate | Rattus norvegicus | ? | - |
? | |
ATP + glycogen synthase | at high concentration, from rabbit skeletal muscle | Rattus norvegicus | ADP + phosphoglycogen synthase | - |
? | |
ATP + phosphorylase b | best substrate | Rattus norvegicus | ADP + phosphorylase a | - |
? | |
ATP + phosphorylase b | liver (rat) | Rattus norvegicus | ADP + phosphorylase a | - |
? | |
ATP + phosphorylase b | cosubstrate: Mg-ATP complex | Rattus norvegicus | ADP + phosphorylase a | - |
? | |
ATP + phosphorylase b | liver | Rattus norvegicus | ADP + phosphorylase a | - |
? | |
ATP + phosphorylase b | rabbit skeletal muscle | Rattus norvegicus | ADP + phosphorylase a | - |
? | |
additional information | histone II-A is no substrate | Rattus norvegicus | ? | - |
? | |
additional information | phosvitin is no substrate | Rattus norvegicus | ? | - |
? | |
additional information | no substrate is histone V-S | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
influence of activation by protein kinase on pH-activity profile | Rattus norvegicus |
7 | - |
nonactivated enzyme | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 7.6 | about half-maximal activity at pH 6.2 and 7.6, nonactivated enzyme | Rattus norvegicus |