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Literature summary for 2.7.11.17 extracted from

  • Pandey, D.; Gratton, J.P.; Rafikov, R.; Black, S.M.; Fulton, D.J.
    Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5 (2011), Mol. Pharmacol., 80, 407-415.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NADPH oxidase 5 Homo sapiens the enzyme mediates the phosphorylation and activation of NADPH oxidase 5. The ability of Ca2+/calmodulin-dependent protein kinase to regulate NADPH oxidase 5 activity may be significant in the regulation of production of reactive oxygen species that occurs downstream of calcium-mobilizing agonists such as angiotensin II. Of these phosphorylation sites, mutation of only Ser475 to alanine prevents Ca2+/calmodulin-dependent protein kinase-induced increases in activity of NADPH oxidase 5 ADP + phosphoraletd NADPH oxidase 5
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NADPH oxidase 5 the enzyme mediates the phosphorylation and activation of NADPH oxidase 5. The ability of Ca2+/calmodulin-dependent protein kinase to regulate NADPH oxidase 5 activity may be significant in the regulation of production of reactive oxygen species that occurs downstream of calcium-mobilizing agonists such as angiotensin II. Of these phosphorylation sites, mutation of only Ser475 to alanine prevents Ca2+/calmodulin-dependent protein kinase-induced increases in activity of NADPH oxidase 5 Homo sapiens ADP + phosphoraletd NADPH oxidase 5
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ATP + NADPH oxidase 5 phosphorylation on Thr494, Ser498, Ser475, Ser502, and Ser675 Homo sapiens ADP + phosphoraletd NADPH oxidase 5
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General Information

General Information Comment Organism
physiological function the enzyme can positively regulate NADPH oxidase 5 activity via the phosphorylation of Ser475. The ability of Ca2+/calmodulin-dependent protein kinase to regulate NADPH oxidase 5 activity may be significant in the regulation of production of reactive oxygen species that occurs downstream of calcium-mobilizing agonists such as angiotensin II Homo sapiens