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Literature summary for 2.7.11.17 extracted from

  • Maier, L.S.; Bers, D.M.
    Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart (2007), Cardiovasc. Res., 73, 631-640.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Mus musculus
Calmodulin dependent on Homo sapiens
Calmodulin dependent on Oryctolagus cuniculus
additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Mus musculus
additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Homo sapiens
additional information after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole Oryctolagus cuniculus

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of isozyme CaMKIIdeltaC in transgenic mouse myocytes or in rabbit myocytes using adenoviral transfection, affects on Ca2+ influx, Ca2+ current, and inhibition of Ca2+ channel inhibition through phosphorylation, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AC3-I peptide i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Mus musculus
AIP peptide i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Mus musculus
KN62 inhibits CaMKII Homo sapiens
KN62 inhibits CaMKII Mus musculus
KN62 inhibits CaMKII Oryctolagus cuniculus
KN93 inhibits CaMKII Homo sapiens
KN93 inhibits CaMKII Mus musculus
KN93 inhibits CaMKII Oryctolagus cuniculus
additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Homo sapiens
additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Mus musculus
additional information the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding Oryctolagus cuniculus
peptide AC3-I i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Homo sapiens
peptide AC3-I i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII Oryctolagus cuniculus
peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Homo sapiens
peptide AIP i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-
sarcoplasmic reticulum associated Mus musculus 16529
-
sarcoplasmic reticulum associated Homo sapiens 16529
-
sarcoplasmic reticulum associated Oryctolagus cuniculus 16529
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mus musculus
Ca2+ dependent on Homo sapiens
Ca2+ dependent on Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-type Ca2+ channel Mus musculus inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel Homo sapiens inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel Oryctolagus cuniculus inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + PLB Mus musculus a regulatory protein in Ca2+ signaling ADP + phosphorylated PLB
-
?
ATP + protein PLB Homo sapiens a regulatory protein in Ca2+ signaling ADP + phosphorylated protein PLB
-
?
ATP + protein PLB Oryctolagus cuniculus a regulatory protein in Ca2+ signaling ADP + phosphorylated protein PLB
-
?
ATP + protein RyR Homo sapiens a regulatory protein in Ca2+ signaling ADP + phosphorylated protein RyR
-
?
ATP + protein RyR Oryctolagus cuniculus a regulatory protein in Ca2+ signaling ADP + phosphorylated protein RyR
-
?
ATP + RyR Mus musculus a regulatory protein in Ca2+ signaling ADP + phosphorylated RyR
-
?
additional information Mus musculus modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
?
additional information Homo sapiens modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
?
additional information Oryctolagus cuniculus modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CaMKII is autophosphorylated Mus musculus
phosphoprotein CaMKII is autophosphorylated Homo sapiens
phosphoprotein CaMKII is autophosphorylated Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-
heart
-
Homo sapiens
-
heart
-
Oryctolagus cuniculus
-
myocyte
-
Mus musculus
-
myocyte
-
Homo sapiens
-
myocyte
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Mus musculus ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Homo sapiens ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias Oryctolagus cuniculus ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel inactivation by CaMKII Mus musculus ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel inactivation by CaMKII Homo sapiens ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + L-type Ca2+ channel inactivation by CaMKII Oryctolagus cuniculus ADP + phosphorylated L-type Ca2+ channel
-
?
ATP + PLB a regulatory protein in Ca2+ signaling Mus musculus ADP + phosphorylated PLB
-
?
ATP + protein PLB a regulatory protein in Ca2+ signaling Homo sapiens ADP + phosphorylated protein PLB
-
?
ATP + protein PLB a regulatory protein in Ca2+ signaling Oryctolagus cuniculus ADP + phosphorylated protein PLB
-
?
ATP + protein RyR a regulatory protein in Ca2+ signaling Homo sapiens ADP + phosphorylated protein RyR
-
?
ATP + protein RyR a regulatory protein in Ca2+ signaling Oryctolagus cuniculus ADP + phosphorylated protein RyR
-
?
ATP + RyR a regulatory protein in Ca2+ signaling Mus musculus ADP + phosphorylated RyR
-
?
additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Mus musculus ?
-
?
additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Homo sapiens ?
-
?
additional information modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview Oryctolagus cuniculus ?
-
?
additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Mus musculus ?
-
?
additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Homo sapiens ?
-
?
additional information CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview Oryctolagus cuniculus ?
-
?

Subunits

Subunits Comment Organism
monomer CaMKIV and CaMKI Mus musculus
monomer CaMKIV and CaMKI Homo sapiens
monomer CaMKIV and CaMKI Oryctolagus cuniculus
multimer CaMKII, homo-and heteromultimers Mus musculus
multimer CaMKII, homo-and heteromultimers Homo sapiens
multimer CaMKII, homo-and heteromultimers Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
CaMKI
-
Mus musculus
CaMKI
-
Homo sapiens
CaMKI
-
Oryctolagus cuniculus
CaMKII
-
Mus musculus
CaMKII
-
Homo sapiens
CaMKII
-
Oryctolagus cuniculus
CaMKIV
-
Mus musculus
CaMKIV
-
Homo sapiens
CaMKIV
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Homo sapiens
ATP
-
Oryctolagus cuniculus