Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Mus musculus | |
Calmodulin | dependent on | Homo sapiens | |
Calmodulin | dependent on | Oryctolagus cuniculus | |
additional information | after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole | Mus musculus | |
additional information | after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole | Homo sapiens | |
additional information | after Ca2+/calmodulin-dependent activation CaMKII is further activated by autophosphorylation at Thr287, this activation is retained even after decline of Ca2+ during diastole | Oryctolagus cuniculus |
Cloned (Comment) | Organism |
---|---|
overexpression of isozyme CaMKIIdeltaC in transgenic mouse myocytes or in rabbit myocytes using adenoviral transfection, affects on Ca2+ influx, Ca2+ current, and inhibition of Ca2+ channel inhibition through phosphorylation, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AC3-I peptide | i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII | Mus musculus | |
AIP peptide | i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL | Mus musculus | |
KN62 | inhibits CaMKII | Homo sapiens | |
KN62 | inhibits CaMKII | Mus musculus | |
KN62 | inhibits CaMKII | Oryctolagus cuniculus | |
KN93 | inhibits CaMKII | Homo sapiens | |
KN93 | inhibits CaMKII | Mus musculus | |
KN93 | inhibits CaMKII | Oryctolagus cuniculus | |
additional information | the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding | Homo sapiens | |
additional information | the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding | Mus musculus | |
additional information | the enzyme contains an autoinhibitory region close to the active site, which sterically blocks substrate binding | Oryctolagus cuniculus | |
peptide AC3-I | i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII | Homo sapiens | |
peptide AC3-I | i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII | Oryctolagus cuniculus | |
peptide AIP | i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL | Homo sapiens | |
peptide AIP | i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
sarcoplasmic reticulum | associated | Mus musculus | 16529 | - |
sarcoplasmic reticulum | associated | Homo sapiens | 16529 | - |
sarcoplasmic reticulum | associated | Oryctolagus cuniculus | 16529 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus | |
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-type Ca2+ channel | Mus musculus | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | Homo sapiens | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | Oryctolagus cuniculus | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + PLB | Mus musculus | a regulatory protein in Ca2+ signaling | ADP + phosphorylated PLB | - |
? | |
ATP + protein PLB | Homo sapiens | a regulatory protein in Ca2+ signaling | ADP + phosphorylated protein PLB | - |
? | |
ATP + protein PLB | Oryctolagus cuniculus | a regulatory protein in Ca2+ signaling | ADP + phosphorylated protein PLB | - |
? | |
ATP + protein RyR | Homo sapiens | a regulatory protein in Ca2+ signaling | ADP + phosphorylated protein RyR | - |
? | |
ATP + protein RyR | Oryctolagus cuniculus | a regulatory protein in Ca2+ signaling | ADP + phosphorylated protein RyR | - |
? | |
ATP + RyR | Mus musculus | a regulatory protein in Ca2+ signaling | ADP + phosphorylated RyR | - |
? | |
additional information | Mus musculus | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | ? | - |
? | |
additional information | Homo sapiens | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | ? | - |
? | |
additional information | Oryctolagus cuniculus | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | CaMKII is autophosphorylated | Mus musculus |
phosphoprotein | CaMKII is autophosphorylated | Homo sapiens |
phosphoprotein | CaMKII is autophosphorylated | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
heart | - |
Oryctolagus cuniculus | - |
myocyte | - |
Mus musculus | - |
myocyte | - |
Homo sapiens | - |
myocyte | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-type Ca2+ channel | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | Mus musculus | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | Homo sapiens | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias | Oryctolagus cuniculus | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | inactivation by CaMKII | Mus musculus | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | inactivation by CaMKII | Homo sapiens | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + L-type Ca2+ channel | inactivation by CaMKII | Oryctolagus cuniculus | ADP + phosphorylated L-type Ca2+ channel | - |
? | |
ATP + PLB | a regulatory protein in Ca2+ signaling | Mus musculus | ADP + phosphorylated PLB | - |
? | |
ATP + protein PLB | a regulatory protein in Ca2+ signaling | Homo sapiens | ADP + phosphorylated protein PLB | - |
? | |
ATP + protein PLB | a regulatory protein in Ca2+ signaling | Oryctolagus cuniculus | ADP + phosphorylated protein PLB | - |
? | |
ATP + protein RyR | a regulatory protein in Ca2+ signaling | Homo sapiens | ADP + phosphorylated protein RyR | - |
? | |
ATP + protein RyR | a regulatory protein in Ca2+ signaling | Oryctolagus cuniculus | ADP + phosphorylated protein RyR | - |
? | |
ATP + RyR | a regulatory protein in Ca2+ signaling | Mus musculus | ADP + phosphorylated RyR | - |
? | |
additional information | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | Mus musculus | ? | - |
? | |
additional information | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | Homo sapiens | ? | - |
? | |
additional information | modulating role of CaMK in excitation-contraction coupling in the heart in response to Ca2+ levels, excitation-contraction coupling can be modulated by CaMKII by phosphorylation of several important Ca2+ regulatory proteins in the heart, overview | Oryctolagus cuniculus | ? | - |
? | |
additional information | CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview | Mus musculus | ? | - |
? | |
additional information | CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview | Homo sapiens | ? | - |
? | |
additional information | CaMKII performs autophosphorylation, and may also regulate Na+ channels, overview | Oryctolagus cuniculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | CaMKIV and CaMKI | Mus musculus |
monomer | CaMKIV and CaMKI | Homo sapiens |
monomer | CaMKIV and CaMKI | Oryctolagus cuniculus |
multimer | CaMKII, homo-and heteromultimers | Mus musculus |
multimer | CaMKII, homo-and heteromultimers | Homo sapiens |
multimer | CaMKII, homo-and heteromultimers | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
CaMKI | - |
Mus musculus |
CaMKI | - |
Homo sapiens |
CaMKI | - |
Oryctolagus cuniculus |
CaMKII | - |
Mus musculus |
CaMKII | - |
Homo sapiens |
CaMKII | - |
Oryctolagus cuniculus |
CaMKIV | - |
Mus musculus |
CaMKIV | - |
Homo sapiens |
CaMKIV | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Oryctolagus cuniculus |