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Literature summary for 2.7.11.17 extracted from

  • Yamamoto, H.; Hiragami, Y.; Murayama, M.; Ishizuka, K.; Kawahara, M.; Takashima, A.
    Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain (2005), J. Neurochem., 94, 1438-1447.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Homo sapiens
Calmodulin dependent on Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in GT1-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KN-93
-
 Homo sapiens
KN-93
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell soma brain Rattus norvegicus
-
-
cell soma neuron Homo sapiens
-
-
additional information distribution in hippocampal neurons: CaM kinase II is located in neurites and neuronal soma Homo sapiens
-
-
neurite
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens
Ca2+ dependent on Rattus norvegicus
Mg2+
-
 Homo sapiens
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tau protein Rattus norvegicus phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development ADP + phosphorylated tau protein
-
 ?
ATP + tau protein Homo sapiens phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain ADP + phosphorylated tau protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme CaM kinase IIalpha
-
Rattus norvegicus
-
 isozyme CaM kinase IIalpha
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex, soma, Alzheimer's disease brain Homo sapiens
-
brain soma Rattus norvegicus
-
hippocampus primary hippocampal neurons Homo sapiens
-
hippocampus primary hippocampal neurons Rattus norvegicus
-
neuron primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells Homo sapiens
-
neuron primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tau peptide 408-420 recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Homo sapiens ADP + phosphorylated tau peptide 408-420
-
 ?
ATP + tau peptide 408-420 recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Rattus norvegicus ADP + phosphorylated tau peptide 408-420
-
 ?
ATP + tau protein phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development Rattus norvegicus ADP + phosphorylated tau protein
-
 ?
ATP + tau protein phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain Homo sapiens ADP + phosphorylated tau protein
-
 ?
ATP + tau protein recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Homo sapiens ADP + phosphorylated tau protein
-
 ?
ATP + tau protein recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 Rattus norvegicus ADP + phosphorylated tau protein
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Homo sapiens
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaM kinase II
-
 Homo sapiens
CaM kinase II
-
 Rattus norvegicus
CaM kinase IIalpha
-
 Homo sapiens
CaM kinase IIalpha
-
 Rattus norvegicus
More cf. EC 2.7.11.26 Homo sapiens
More cf. EC 2.7.11.26 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus