Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | isozyme PKCalpha is not inhibited by H-89 and rottlerin | Homo sapiens | |
Ro-31-7549 | specific inhibitor for isozyme PKCalpha | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0166 | - |
FKKQGSFAKKK | isozyme PKCeta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0174 | - |
FKKQGSFAKKK | isozyme PKCalpha, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0205 | - |
FKKQGSFAKKK | isozyme PKCzeta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0229 | - |
FKKQGSFAKKK | isozyme PKCepsilon, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0258 | - |
FKKQGSFAKKK | isozyme PKCiota/lambda, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.034 | - |
FKKQGSFAKKK | isozyme PKCtheta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0347 | - |
FKKQGSFAKKK | isozyme PKCgamma, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0356 | - |
FKKQGSFAKKK | isozyme PKCbetaI, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0422 | - |
FKKQGSFAKKK | isozyme PKCdelta, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens | |
0.0599 | - |
FKKQGSFAKKK | isozyme PKCbetaII, in 20 mM Tris-HCl, pH 7.5, 10 mM MgCl2, and 0.1 mM CaCl2, at 25°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05129 | - |
- |
Homo sapiens | P05771 | - |
- |
Homo sapiens | P17252 | - |
- |
Homo sapiens | P24723 | - |
- |
Homo sapiens | P41743 | - |
- |
Homo sapiens | Q02156 | - |
- |
Homo sapiens | Q04759 | - |
- |
Homo sapiens | Q05513 | - |
- |
Homo sapiens | Q05655 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | - |
Homo sapiens | - |
breast cancer cell | shows higher levels of PKCalpha than normal breast tissue | Homo sapiens | - |
Hep-G2 cell | shows higher levels of PKCalpha than normal liver tissue | Homo sapiens | - |
liver | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + FKKQGSFAKKK | highly specific substrate for isozyme PKCalpha relative to other isozymes, 60% phosphorylation rate with isozyme PKCalpha, less than 20% phosphorylation rate with other PKC isozymes | Homo sapiens | ADP + phosphorylated FKKQGSFAKKK | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKCalpha | isozyme | Homo sapiens |
PKCbeta1 | isozyme | Homo sapiens |
PKCbeta2 | isozyme | Homo sapiens |
PKCdelta | isozyme | Homo sapiens |
PKCepsilon | isozyme | Homo sapiens |
PKCeta | isozyme | Homo sapiens |
PKCgamma | isozyme | Homo sapiens |
PKCiota/lambda | isozyme | Homo sapiens |
PKCtheta | isozyme | Homo sapiens |
PKCzeta | isozyme | Homo sapiens |