Literature summary for 2.7.11.13 extracted from

Kocanova, S.; Hornakova, T.; Hritz, J.; Jancura, D.; Chorvat, D.; Mateasik, A.; Ulicny, J.; Refregiers, M.; Maurizot, J.C.; Miskovsky, P.
Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells (2006), Photochem. Photobiol., 82, 720-728.

Search for more literature for 2.7.11.13

Activating Compound

Activating Compound	Comment	Organism	Structure
12-O-Tetradecanoylphorbol 13-acetate	modeling of complex formation with PKCgamma, competes with hypericin for binding to the regulatory domain of PKC	Homo sapiens
hypericin	competes with 12-O-tetradecanoylphorbol 13-acetate for binding to the regulatory domain of PKC, localization of PKC isozymes alpha, delta, and gamma, high affinty binding and interaction witht he C1B domain of PKC, molecular modeling	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	binding kinetics of PKC isozymes to hypericin and phorbol esters, overview	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
intracellular	localization of PKC isozymes alpha, delta, and gamma, is influenced by hypericin, high affinity binding and interaction with the C1B domain of PKC, molecular modeling	Homo sapiens	5622	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioma cell	-	Homo sapiens	-
U-87MG cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PKC	-	Homo sapiens

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Release 2023.1 (January 2023)