Protein Variants | Comment | Organism |
---|---|---|
K368A | a dominant-negative mutant of PKCalpha | Mus musculus |
K368A | a dominant-negative mutant of PKCalpha | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
angiotensin II type 2-receptor | inhibits isozyme PKCalpha | Mus musculus | |
angiotensin II type 2-receptor | inhibits isozyme PKCalpha | Rattus norvegicus | |
Gö6976 | inhibits classical isozymes | Mus musculus | |
Gö6976 | inhibits classical isozymes | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
Ca2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
82000 | - |
x * 82000, isozyme PKCalpha, SDS-PAGE | Mus musculus |
82000 | - |
x * 82000, isozyme PKCalpha, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview | ? | - |
? | |
additional information | Rattus norvegicus | involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
NG-108-15 cell | a hybridomal cell line of a rat neuroblastoma and a mouse glioma, expression of isozymes PKCalpha, PKCepsilon, PKCjota, and PKCzeta, no expression of isozymes PKCbeta, PKCdelta, PKCgamma, PKCmy, and PKCtheta | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview | Mus musculus | ? | - |
? | |
additional information | involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 82000, isozyme PKCalpha, SDS-PAGE | Mus musculus |
? | x * 82000, isozyme PKCalpha, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Mus musculus |
PKC | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Rattus norvegicus |