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Literature summary for 2.7.11.13 extracted from

  • Beaudry, H.; Gendron, L.; Guimond, M.O.; Payet, M.D.; Gallo-Payet, N.
    Involvement of protein kinase C alpha (PKC alpha) in the early action of angiotensin II type 2 (AT2) effects on neurite outgrowth in NG108-15 cells: AT2-receptor inhibits PKC alpha and p21ras activity (2006), Endocrinology, 147, 4263-4272.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K368A a dominant-negative mutant of PKCalpha Mus musculus
K368A a dominant-negative mutant of PKCalpha Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
angiotensin II type 2-receptor inhibits isozyme PKCalpha Mus musculus
angiotensin II type 2-receptor inhibits isozyme PKCalpha Rattus norvegicus
Gö6976 inhibits classical isozymes Mus musculus
Gö6976 inhibits classical isozymes Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Mus musculus
-
-
soluble
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Mus musculus
Ca2+
-
Rattus norvegicus
Mg2+
-
Mus musculus
Mg2+
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
82000
-
x * 82000, isozyme PKCalpha, SDS-PAGE Mus musculus
82000
-
x * 82000, isozyme PKCalpha, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview ?
-
?
additional information Rattus norvegicus involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
NG-108-15 cell a hybridomal cell line of a rat neuroblastoma and a mouse glioma, expression of isozymes PKCalpha, PKCepsilon, PKCjota, and PKCzeta, no expression of isozymes PKCbeta, PKCdelta, PKCgamma, PKCmy, and PKCtheta Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview Mus musculus ?
-
?
additional information involvement of isozyme PKCalpha in the early action of angiotensin II type 2 effects on neurite outgrowth in NG108-15 cells, the angiotensin II type 2-receptor inhibits PKC alpha and p21ras activity, inhibition of PKCalpha is not directly involved in the Rap1-MEK-p42/p44mapk cascade, overview Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
? x * 82000, isozyme PKCalpha, SDS-PAGE Mus musculus
? x * 82000, isozyme PKCalpha, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PKC
-
Mus musculus
PKC
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus
ATP
-
Rattus norvegicus