Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-Tetradecanoylphorbol 13-acetate | activates PKCalpha isozyme about 1.6fold | Homo sapiens | |
additional information | no activation by 4alpha-phorbol-12,13-didecanoate | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant isoyzem PKCalpha in COS-7 cells, co-expression of PKCalpha with diacylglycerol kinase-zeta and retinoblastoma protein in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K368D | site-directed mutagenesis of isozyme PKCalpha ATP-binding site, a dominant-negative mutant | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + diacylglycerol kinase-zeta | Homo sapiens | the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein | ADP + phosphorylated diacylglycerol kinase-zeta | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme pKCalpha | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + diacylglycerol kinase-zeta | the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein | Homo sapiens | ADP + phosphorylated diacylglycerol kinase-zeta | - |
? | |
ATP + diacylglycerol kinase-zeta | isozyme PKCalpha | Homo sapiens | ADP + phosphorylated diacylglycerol kinase-zeta | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |