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Literature summary for 2.7.11.13 extracted from

  • Los, A.P.; de Widt, J.; Topham, M.K.; van Blitterswijk, W.J.; Divecha, N.
    Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein (2007), Biochim. Biophys. Acta, 1773, 352-357.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
12-O-Tetradecanoylphorbol 13-acetate activates PKCalpha isozyme about 1.6fold Homo sapiens
additional information no activation by 4alpha-phorbol-12,13-didecanoate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant isoyzem PKCalpha in COS-7 cells, co-expression of PKCalpha with diacylglycerol kinase-zeta and retinoblastoma protein in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K368D site-directed mutagenesis of isozyme PKCalpha ATP-binding site, a dominant-negative mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + diacylglycerol kinase-zeta Homo sapiens the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein ADP + phosphorylated diacylglycerol kinase-zeta
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme pKCalpha
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + diacylglycerol kinase-zeta the enzyme, especially isozyme PKCalpha, inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein Homo sapiens ADP + phosphorylated diacylglycerol kinase-zeta
-
 ?
ATP + diacylglycerol kinase-zeta isozyme PKCalpha Homo sapiens ADP + phosphorylated diacylglycerol kinase-zeta
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens