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Literature summary for 2.7.11.13 extracted from
- Protein kinase C and beyond (2004), Nat. Immunol., 5, 785-790.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| diacylglycerol | binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview | Mus musculus |  |
| diacylglycerol | binds to C1 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta, overview | Homo sapiens | |
| additional information | activation mechanism of isozymes, overview | Mus musculus | |
| additional information | activation mechanism of isozymes, overview | Homo sapiens | |
| phorbol 12,13-dibutyrate | - |
Mus musculus | |
| phorbol 12,13-dibutyrate | - |
Homo sapiens | |
| phorbol 12-myristate 13-acetate | - |
Mus musculus | |
| phorbol 12-myristate 13-acetate | - |
Homo sapiens | |
| Phospholipids | regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta | Mus musculus | |
| Phospholipids | regulatory function for isozymes alpha, betaI, betaII, gamma, delta, epsilon, eta, and theta | Homo sapiens | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of isozyme PKCtheta T-cell knockout mice, which show slightly impaired immune system and are defective in NF-kappaB activation, overview, isozyme PKCdelta knockout mice show a deregulated immune system, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bisindolylmaleimide derivatives | - |
Homo sapiens | |
| bisindolylmaleimide derivatives | - |
Mus musculus | |
| rottlerin | inhibits PKCdelta | Homo sapiens | |
| rottlerin | inhibits PKCdelta | Mus musculus | |
| staurosporine | PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus | Homo sapiens | |
| staurosporine | PKC inhibitory alkaloid isolated from the bacterium Lentzea albida, formerly Streptomyces staurosporeus | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | Mus musculus | - |
- |
| additional information | isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | Homo sapiens | - |
- |
| plasma membrane | PKC is recruited by other kinases | Mus musculus | 5886 | - |
| plasma membrane | PKC is recruited by other kinases | Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | binds to C2 domain of PKC, regulatory fucntion for isozymes alpha, betaI, betaII, and gamma, overview | Homo sapiens | |
| Ca2+ | binds to C2 domain of PKC, regulatory function for isozymes alpha, betaI, betaII, and gamma, overview | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phosphoinositide-dependent kinase | Mus musculus | phosphoinositide-dependent kinases are conserved substrates of PKC | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| ATP + phosphoinositide-dependent kinase | Homo sapiens | phosphoinositide-dependent kinases are conserved substrates of PKC | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| additional information | Solanum lycopersicum | PKC isozymes are involved in signal transduction, required for defense against fungal infection | ? | - |
? | |
| additional information | Caenorhabditis elegans | PKC isozymes are involved in signal transduction, required for host defense | ? | - |
? | |
| additional information | Homo sapiens | PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | ? | - |
? | |
| additional information | Mus musculus | PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta | - |
| Homo sapiens | - |
multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta, and atypical isozymes zeta and jota | - |
| Mus musculus | - |
multiple isozymes: classical isozymes alpha, betaI, betaII, and gamma, novel isozymes delta, epsilon, eta, and theta, and atypical isozymes zeta and lambda | - |
| Solanum lycopersicum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-lymphocyte | - |
Mus musculus | - |
| B-lymphocyte | - |
Homo sapiens | - |
| plant | - |
Solanum lycopersicum | - |
| T-lymphocyte | - |
Mus musculus | - |
| T-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phosphoinositide-dependent kinase | phosphoinositide-dependent kinases are conserved substrates of PKC | Mus musculus | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| ATP + phosphoinositide-dependent kinase | phosphoinositide-dependent kinases are conserved substrates of PKC | Homo sapiens | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| ATP + phosphoinositide-dependent kinase | i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD | Mus musculus | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| ATP + phosphoinositide-dependent kinase | i.e. PDK, phosphorylation at Ser744 and Ser748 in the activation loop of the catalytic domain of PKD, reaction is regulated by diacylglycerol | Homo sapiens | ADP + phosphorylated phosphoinositide-dependent kinase | - |
? | |
| additional information | PKC isozymes are involved in signal transduction, required for defense against fungal infection | Solanum lycopersicum | ? | - |
? | |
| additional information | PKC isozymes are involved in signal transduction, required for host defense | Caenorhabditis elegans | ? | - |
? | |
| additional information | PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | Homo sapiens | ? | - |
? | |
| additional information | PKCtheta is important in regulation of immune response in T-cells, overview, PKC is involved in NF-kappaB activation pathways in vivo, overview, PKCdelta acts as negative regulator by feedback inhibition of the CDgamma3 subunit important for immune response in T lymphocytes, overview, PKC isozymes are involved in signal transduction, and thereby in cell adhesion and migration, isozyme PKCtheta is recruited to the plasma membrane by a cytoskeleton-dependent mechanism regulating the Rac-1 guanine nucelotide exchange protein Vav-1 | Mus musculus | ? | - |
? | |
| additional information | regulatory interactions of isozymes with other kinases, overview | Mus musculus | ? | - |
? | |
| additional information | regulatory interactions of isozymes with other kinases, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKC | - |
Mus musculus |
| PKC | - |
Homo sapiens |
| PKC | - |
Caenorhabditis elegans |
| PKC-like kinase | - |
Solanum lycopersicum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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